Table 5 Summary of previous studies examining GSTM1 and GSTT1 polymorphisms and hypertension risk
Country | Population (Cases/controls) | Ethnicity | Genotyping method | association with the risk of hypertension | Years | First author/ references |
|---|---|---|---|---|---|---|
Portugal | Hypertension/congestive heart failure (94/207) | Caucasian | PCR | GSTT1-active | 2007 | Marinho [49] |
Egypt | General population (40/40) | African | Multiplex PCR | GSTM1-null/GSTT1-null | 2009 | Bessa [24] |
Italy | Older subjects (255/99) | Caucasian | PCR | GSTM1-null | 2009 | Capoluongo [25] |
India | Tea garden workers (223/236) | Asian | Multiplex PCR | GSTM1-null; GSTT1-null (in smokers) | 2011 | Borah [26] |
Italy | General population (193/210) | Caucasian | Multiplex PCR | GSTT1-null (women) | 2011 | Polimanti [27] |
Korea | General population (227/130) | Asian | PCR | GSTM1-null | 2011 | Han [47] |
United Arab Emirates | General population (30/33) | Asian | Multiplex PCR | none | 2012 | Hussain [29] |
Korea | Lead-exposed workers (258/497) | Asian | Multiplex PCR | GSTT1-active | 2012 | Lee [50] |
Slovenia | hypertension/type 2 diabetes (1015) | Caucasian | Multiplex PCR | GSTM1-null GSTT1-null | 2014 | Petrovic [51] |
India | General population (138/116) | Asian | Multiplex PCR | GSTT1-null; GSTM1-active | 2015 | Abbas [48] |