ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population

Table 6 Association between cardiovascular risk and sUA concentration and HUA risk among ABCG2 T allele carriers

Cardiovascular risk factors	sUA		hyperuricemia
Cardiovascular risk factors	Beta (SE)	p*	OR 95%CI	p*
Total population
BMI	0.21 (0.60)	3.40 × 10⁻⁸	1.42 (1.28–1.56)	4.25 × 10⁻¹²
Hypertension	0.036 (6.01)	0.978	1.35 (0.85–2.13)	0.206
TG	0.24 (3.67)	6.18 × 10⁻⁹	1.90 (1.44–2.50)	4.08 × 10⁻⁶
LDL	0.025 (3.77)	0.506	1.28 (0.94–1.74)	0.114
HDL	−0.042 (10.76)	0.311	0.69 (0.25–1.90)	0.471
Male
BMI	0.23 (1.27)	1.14 × 10⁻⁵	2.01 (1.62–2.50)	1.75 × 10⁻¹⁰
Hypertension	0.022 (7.83)	0.657	1.37 (0.74–2.54)	0.319
TG	0.25 (4.72)	8.95 × 10⁻⁶	1.88 (1.28–2.74)	0.001
LDL	0.015 (5.27)	0.761	1.40 (0.84–2.32)	0.192
HDL	−0.063 (14.92)	0.264	0.52 (0.11–2.41)	0.407
Female
BMI	0.20 (1.48)	0.002	1.22 (1.08–1.37)	0.001
Hypertension	0.054 (9.45)	0.370	1.27 (0.63–2.55)	0.498
TG	0.24 (5.93)	4.00 × 10⁻⁴	1.95 (1.26–3.03)	0.003
LDL	0.073 (5.44)	0.231	1.30 (0.87–1.41)	0.208
HDL	0.025 (15.72)	0.711	0.83 (0.19–3.70)	0.798

*p value for the logistic regression adjusted by age, gender, serum cretinine, BMI, hypertension, TG, LDL, and HDL

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