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Table 3 Association of urolithiasis risk with of SPP1 genetic variants considering haplotype analysis

From: Osteopontin promoter polymorphisms and risk of urolithiasis: a candidate gene association and meta-analysis study

SPP1 haplotypes (rs2853744:G > T- rs11730582:T > C- rs11439060:delG > G)

Haplotype frequency†

Case, control ratios

OR (95% CI)

p-value (corrected)‡

G-T-dG

0.323

0.313, 0.332

Referent

–

G-C-dG

0.312

0.374, 0.248

1.68 (1.15–2.46)

0.0079

G-C-G

0.090

0.086, 0.107

0.95 (0.57–1.58)

0.840

G-T-G

0.078

0.079, 0.068

1.25 (0.61–2.56)

0.550

T-T-dG

0.060

0.083, 0.053

1.43 (0.72–2.87)

0.310

T-C-dG

0.059

0.025, 0.081

0.53 (0.24–1.17)

0.120

  1. OR Odds ratio; 95% CI 95% confidence interval
  2. †Haplotypes with a frequency > 5% were analyzed
  3. ‡p-values are corrected for age and gender. p-value adjustment for multiple testing using Bonferroni method was also made (p-value threshold 0.0083). Statistical significance is highlighted in bold
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BMC Medical Genetics

ISSN: 1471-2350

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