Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations

BMC Medical Genetics

Table 3 Association between BMI and selected genotypes adjusted for vitamin D levels and DBP

Parameter	B	Std. error	P-value	Explained variance (eta-square)
rs11023374	1.080	0.444	0.015	1.6%
rs2853564	−1.557	0.633	0.014	1.6%
rs7302235	−0.699	0.453	0.124	0.6%
calculated genetic effect			NA	3.2%
t-25OH-vitamin D	0.019	0.082	0.858	0%
f-25OH-vitamin D	0.296	0.224	0.751	0%
DBP	−0.016	0.005	0.002	2.5%

Multiple linear regression with BMI as dependent and SNPs with significant univariate association (rs11023374, rs2853564, rs7302235) and DBP, t-25OHD, f-25OHD as covariates
Abbreviations: b-25OHD bioactive 25-hydroxyvitamin D, DBP vitamin D binding protein, f-25OHD free 25-hydroxyvitamin D, t-25OHD total 25-hydroxyvitamin D

ISSN: 1471-2350