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Fig. 2 | BMC Medical Genetics

Fig. 2

From: A novel pathogenic variant in the LRTOMT gene causes autosomal recessive non-syndromic hearing loss in an Iranian family

Fig. 2

Protein structure modeling of wild-type and mutated LRTOMT. a the merged image of wild-type LRTOMT is shown in purple and mutanted LRTOMT in cyan. A part of the amino acid sequence has been eliminated in the mutated protein compared to the wild type protein (b) the catechol-O-methyltransferase domain, as a functional domain, is shown in yellow and in the figure (c) the modified COMT domain in the mutanted protein is defined in gray. The affected amino acids (residue 170–291) are a part of catalitic domain

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BMC Medical Genetics

ISSN: 1471-2350

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