Fig. 4

Plots of \( \ln {\hat{LR}}_W \) for the associations between rare variants around MAPT (± 10 M bp) located on chromosome 17 and log-transformed CSF phosphorylated tau levels in ADNI. Positive \( \ln {\hat{LR}}_W \) represents test statistics for \( {\hat{\mu}}_{W_{+}}>{\hat{\mu}}_{W_{-}} \) and negatives for \( {\hat{\mu}}_{W_{+}}<{\hat{\mu}}_{W_{-}} \)