Table 5 Synergistically combined genotype frequencies of TNF-α-308 G/A and INF-γ 874 A/T in different species of leishmaniasis and healthy human controls
L. major 102 (%) | Healthy human controls 199 (%) | P value | OR (95%CI) | |
|---|---|---|---|---|
TNF-α 308 G/A | ||||
Low (GG) | 60 (58.8) | 130 (65.3) | ||
High (GA + AA) | 42 (41.2) | 69 (34.7) | ||
INF-γ 874 A/T | ||||
Low (AA) | 28 (27.5) | 76 (38.2) | ||
High (AT+TT) | 74 (72.5) | 123 (61.8) | ||
TNF-α with INF-γ | ||||
Low/ low | 18 (17.6) | 51 (25.6) | 0.1 | 0.6 (0.3 to1.1) |
Low/ high | 42 (41.2) | 89 (44.7) | 0.5 | 0.8 (0.5 to 1.4) |
High/ low | 10 (9.8) | 25 (12.6) | 0.4 | 0.7 (0.3 to 1.6) |
High/ high | 32 (31.4) | 34 (17.1) | P** 0.005 | 2.2 (1.2 to 3.8) |
L. tropica 59 (%) | Healthy human controls 199 (%) | |||
TNF-α 308 G/A | ||||
Low (GG) | 35 (59.3) | 130 (65.3) | ||
High (GA + AA) | 24 (40.7) | 69 (34.7) | ||
INF-γ 874 A/T | ||||
Low (AA) | 18 (30.5) | 76 (38.2) | ||
High (AT+TT) | 41 (69.5) | 123 (61.8) | ||
TNF-α 308 / INF-γ 874 | ||||
Low/ low | 15 (25.4) | 51 (25.6) | 0.7 | 0.8 (0.3 to 1.7) |
Low/ high | 20 (33.9) | 89 (44.7) | 0.1 | 0.6 (0.3 to 1.1) |
High/ low | 3 (5.1) | 25 (12.6) | 0.1 | 0.3 (0.1 to 1.3) |
High/ high | 21 (35.6) | 34 (17.1) | P** 0.003 | 2.7 (1.4 to 5.1) |
Totalleishmaniacases 169 (%) | Healthy human controls 199 (%) | |||
TNF-α 308 G/A | ||||
Low (GG) | 100 (59.2) | 130 (65.3) | ||
High (GA + AA) | 69 (40.8) | 69 (34.7) | ||
INF-γ 874 A/T | ||||
Low (AA) | 49 (29.0) | 76 (38.2) | ||
High (AT+TT) | 120 (71.0) | 123 (61.8) | ||
TNF-α 308 / INF-γ 874 | ||||
Low/ low | 36 (21.3) | 51 (25.6) | 0.3 | 0.7 (0.4 to 1.2) |
Low/ high | 64 (37.9) | 89 (44.7) | 0.1 | 0.7 (0.4 to 1.1) |
High/ low | 15 (8.9) | 25 (12.6) | 0.2 | 0.6 (0.3 to 1.3) |
High/ high | 54 (31.9) | 34 (17.1) | P** 0.001 | 2.2 (1.2 to 3.7) |