Table 3 Genotype frequencies of TNF-α-308 G/A in different species of leishmaniasis and healthy human controls
TNF-α 308 G/A | L. major 102 (%) | Healthy human controls 199 (%) |
Genotypes | ||
GG | 60 (58.8) | 130 (65.3) |
GA | 39 (38.2) | 65 (32.7) |
AA | 3 (3.0) | 4 (2.0) |
Alleles | ||
G | 159 (78) | 325 73 (81.7) |
A | 45 (22) | 73 (18.3) |
Statistics | ||
AA+GA vs. GG (dominant) | P = 0.3 | OR (95%CI) 1.31 [0.8 to 2.2] |
AA vs. GG + GA (recessive) | P = 0.6 | OR (95%CI) 1.5 [0.3 to 6.7] |
A allele vs. G allele | P = 0.3 | OR (95%CI) 1.3 [0.8 to 1.9] |
TNF-α 308 G/A | L. tropica 59 (%) | Healthy human controls 199 (%) |
Genotypes | ||
GG | 35 (59.3) | 130 (65.3) |
GA | 24 (40.7) | 65 (32.7) |
AA | 0 (0) | 4 (2) |
Alleles | ||
G | 91 (79.6) | 325 (81.7) |
A | 27 (20.4) | 73 (18.3) |
Statistics | ||
AA+GA vs. GG (dominant) | P = 0.4 | OR (95%CI) 1.3 [0.7 to 2.3] |
AA vs. GG + GA (recessive) | P = 0.5 | OR (95%CI) 0.4 [0.02 to 7.1] |
A allele vs. G allele | P** =0.0004 | OR (95%CI) 2.2 [1.4 to 3.4] |
TNF-α 308 G/A | L. infantum/donovani complex 8 (%) | Healthy human controls 199 (%) |
Genotypes | ||
GG | 5 (62.5) | 130 (65.3) |
GA | 3 (37.5) | 65 (32.7) |
AA | 0 (0) | 4 (2) |
Alleles | ||
G | 13 (77.4) | 325 (81.7) |
A | 3 (22.6) | 73 (18.3) |
Statistics | ||
ND | ND | ND |
TNF-α 308 G/A | Totalleishmaniacases 169 (%) | Healthy human controls 199 (%) |
Genotypes | ||
GG | 100 (59.2) | 130 (65.3) |
GA | 66 (39.1) | 65 (32.7) |
AA | 3 (1.7) | 4 (2) |
Alleles | ||
G | 266 (78.7) | 325 (81.7) |
A | 72 (21.3) | 73 (18.3) |
Statistics | ||
AA+GA vs. GG (dominant) | P = 0.2 | OR (95%CI) 1.3 [0.9 to 2.0] |
AA vs. GG + GA (recessive) | p = 0.9 | OR (95%CI) 0.9 [0.2 to 4.0] |
A alleles vs. G allele | p = 0.3 | OR (95%CI) 1.2 [0.8 to 1.7] |