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Table 5 Comparisons of clinical characteristics among genotypes rs7754840, rs7138803, and rs6548238

From: Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients

 

rs7754840

P

rs7138803

P

rs6548238

CC + CG

GG

AA+AG

GG

CC + CT

TT

P

Waistcircumference (cm)

96.68 ± 17.31

90.29 ± 14.56

0.040

97.11 ± 16.42

92.53 ± 16.53

0.139

97.27 ± 16.84

90.75 ± 15.66

0.030

Waist/hip ratio

1.11 ± 0.36

0.97 ± 0.25

0.027

1.09 ± 0.30

1.04 ± 0.35

0.345

1.15 ± 0.33

0.95 ± 0.29

0.001

BMI (kg/m2)

26.48 ± 4.98

25.98 ± 5.80

0.612

27.94 ± 4.94

25.25 ± 5.25

0.006

26.94 ± 4.57

22.52 ± 5.98

0.023

FPG (mmol/L)

10.07 ± 4.00

10.14 ± 3.67

0.925

10.97 ± 3.77

9.54 ± 3.85

0.046

11.01 ± 3.80

9.01 ± 3.69

0.004

HbA1c, %

9.90 ± 3.94

9.72 ± 3.36

0.799

10.30 ± 3.74

9.53 ± 3.70

0.268

10.70 ± 4.02

8.78 ± 3.05

0.004

SBP (mm Hg)

132.91 ± 23.98

124.93 ± 17.85

0.039

130.00 (112.00,115.00)

122.00 (110.00,150.00)

0.413

131.39 ± 22.03

128.20 ± 22.39

0.432

DBP (mm Hg)

84.03 ± 11.14

82.13 ± 10.60

0.360

86.45 ± 9.91

81.34 ± 11.16

0.012

85.91 ± 9.91

80.22 ± 11.39

0.004

TG (mmol/L)

4.61 ± 4.38

4.32 ± 3.69

0.705

3.66 (1.98,7.13)

2.62 (1.42,4.84)

0.041

5.46 ± 4.80

3.36 ± 2.76

0.005

TC (mmol/L)

5.39 ± 2.60

5.38 ± 2.60

0.44

5.38 ± 2.60

4.93 ± 2.38

0.324

5.88 ± 2.45

4.51 ± 1.99

0.001

HDL-C (mmol/L)

1.05 ± 0.54

0.98 ± 0.47

0.455

0.92 (0.58,1.06)

0.97 (0.70,1.22)

0.066

0.85 ± 0.36

1.23 ± 0.59

0.001

LDL-C (mmol/L)

2.92 ± 1.01

2.37 ± 0.87

0.176

2.99 ± 0.93

2.72 ± 0.98

0.133

2.98 ± 1.04

2.63 ± 0.85

0.050

FINS (μIU/mL)

22.27 ± 17.33

17.82 ± 10.06

0.076

19.60 (16.56,26.72)

13.18 (8.72,26.10)

0.007

21.50 ± 12.51

19.55 ± 17.88

0.484

HOMA-IR

6.81 (2.98,14.05)

5.60 (3.59,13.86)

0.677

10.46 (3.72,15.07)

5.35 (2.90,12.68)

0.083

10.01 ± 8.52

8.79 ± 7.31

0.399

HOMA-IS

0.010 (0.000,0.020)

0.010 (0.005,0.017)

0.184

0.012 (0.010,0.020)

0.010 (0.000,0.020)

0.662

0.010 (0.000,0.010)

0.016 (0.010,0.020)

0.001