Table 4 Genotypes of seven genetic loci
SNP | Locus | Genotype | Healthy controls n (%) | Overweight diabetes n (%) | Obesity diabetes n (%) | χ2 | P |
|---|---|---|---|---|---|---|---|
rs10938397 | Near GNPDA2 | AA | 85 (44.7) | 63 (50.0) | 54 (43.9) | 4.45 | < 0.001 |
AG | 65 (34.2) | 45 (35.7) | 51 (41.5) | Â | Â | ||
GG | 40 (21.1) | 18 (14.3) | 18 (14.6) | Â | Â | ||
rs7498665 | SH2B1 | AA | 75 (39.5) | 54 (42.9) | 30 (24.4) | 24.73 | < 0.001 |
AG | 70 (36.8) | 63 (50.0) | 63 (51.2) | Â | Â | ||
GG | 45 (23.7) | 9 (7.1) | 30 (24.4) | Â | Â | ||
rs6548238 | Near TMEM18 | TT | 115 (60.5) | 18 (14.3) | 57 (46.3) | 70.53 | < 0.001 |
CT | 5 (2.6) | 12 (9.5) | 12 (9.8) | Â | Â | ||
CC | 70 (36.8) | 96 (76.2) | 54 (43.9) | Â | Â | ||
rs10838738 | MTCH2 | AA | 95 (50.0) | 72 (57.1) | 48 (39.0) | 37.74 | < 0.001 |
AG | 90 (47.4) | 30 (23.8) | 57 (46.3) | Â | Â | ||
GG | 5 (2.6) | 24 (19.1) | 18 (14.6) | Â | Â | ||
rs7754840 | CDKAL1 | CC | 45 (23.7) | 27 (21.5) | 21 (17.1) | 6.73 | 0.15 |
CG | 65 (34.2) | 57 (45.2) | 57 (46.3) | Â | Â | ||
GG | 80 (42.1) | 42 (33.3) | 45 (36.6) | Â | Â | ||
rs7138803 | FAIM2 | GG | 145 (76.3) | 66 (52.4) | 63 (51.2) | 32.16 | < 0.001 |
AG | 40 (21.1) | 42 (33.3) | 45 (36.6) | Â | Â | ||
AA | 5 (2.6) | 18 (14.3) | 15 (12.2) | Â | Â | ||
rs12970134 | Near MC4R | GG | 105 (55.3) | 81 (64.3) | 75 (61.0) | 7.58 | 0.108 |
AG | 60 (31.6) | 39 (31.0) | 39 (31.7) | Â | Â | ||
AA | 25 (13.2) | 6 (4.8) | 9 (7.3) | Â | Â |