Table 1 Cases of CHD2 mutations with behavioral disorders: main psychiatric and cognitive characteristics
From: Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report
Reference | Number of patients | Gender M/F | Mean Age (years) | Behavioral features (Number) | Cognitive profile | Brain MRI |
|---|---|---|---|---|---|---|
[5] | 6 | 4/6 | 14,5 | ASD (2) | Moderate ID (2) Severe ID (4) | NA |
[11] | 4 | NA | NA | ASD (4) | Cognitive impairment (4) | NA |
[14] | 9 (+ 1deletion) | 6/4 | 17,9 | ASD (4) ADHD (1) Challenging behavior (8) Psychotic features (1) | Mild to severe (10) | Progressive atrophy (3) Corpus callosum atrophy (3) Normal during adulthood (2) |
[15] | 2 | 2/0 | NA | ASD | Mild d ID (1/2) | NA |
[16] | 1 | 1/0 | 26 | Hyperactivit Autistic features | Severe ID | Normal |
[17] | 2 | 2/0 | ASD Hyperactivity Developpemental delay Bruxism Stereotypic movements | NA | ||
[18] | 1 | 0/1 | 27 | Limited social skills Psychotic disorder | Moderate ID | NA |