Genetic polymorphisms associated with sleep-related phenotypes; relationships with individual nocturnal symptoms of insomnia in the HUNT study

Table 2 SNPs showing significant p-value before FDR correction

SNP	Ref. allele	Other allele	Gene	Symptoms sub-group	B	OR	95% CI	p-value	Previous associations
rs10493596	T	C	AK5	SOI + TI	−0.82	0.45	[0.3 to 0.8]	0.004	Morning chronotype [2]
rs10823607	T	C	ADAMTS14	SOI + TI	− 0.71	0.5	[0.2 to 0.9]	0.039	Sleep duration [4]
rs113851554	T	G	MEIS1	SOI + MI	0.4	1.5	[1.1 to 2]	0.007	Insomnia symptoms [13]
				SOI + MI + TI	0.36	1.4	[1.1 to 2]	0.007
rs11706236	G	A	CACNA2D3	MI + TI	−0.33	0.7	[0.5 to 0.9]	0.009	Caffeine related insomnia [3]
rs12471454	T	C	SATB2	TI	−0.26	0.8	[0.6 to 1]	0.029	Insomnia [4]
rs12927162	G	A	TOX3	MI	−0.15	0.9	[0.7 to 1]	0.036	Morning chronotype [2]
rs1823125	G	A	PAX8	MI	0.16	1.2	[1 to 1.4]	0.033	Sleep duration [23]
rs1940013	T	C	OPCML	SOI	0.19	1.2	[1 to 1.5]	0.037	Usual bedtime [22]
rs2221285	T	C	ESRRG	SOI + TI	−0.53	0.8	[0.7 to 1]	0.027	Sleep duration [23]
rs2287838	G	A	PIN1	SOI	−0.22	0.8	[0.7 to 1]	0.022	Sleep duration [23]
rs2302729	T	C	CACNA1C	SOI + TI	0.64	1.9	[1.2 to 3]	0.009	Sleep latency [4]
rs34714364	T	G	APH1A	MI	0.16	1.18	[1 to 1.4]	0.041	Morning chronotype [2]
rs55694368	T	G	PER2	MI	−0.19	0.83	[0.7 to 1]	0.043	Morning chronotype [2]
rs6437122	G	C	UPP2	SOI + MI + TI	−0.34	0.7	[0.5 to 0.9]	0.015	Sleep duration [23]
rs9517132	T	C	RANBP5	SOI	−0.22	0.8	[0.7 to 1]	0.018	Usual sleep duration [23]
rs9804200	C	T	EBF3	MI + TI	−0.21	0.81	[0.7 to 1]	0.044	Usual bedtime [4]

ISSN: 1471-2350