Table 3 Genotypic distributions of the rs4132601 T/G and rs11978267 A/G variants between cases and controls according to different models of genetic transmission
SNP | Model | Genotype | Cases (%) | Controls (%) | Â | OR (95% CI) | aP a | P corr b | aOR (95% CI)a |
|---|---|---|---|---|---|---|---|---|---|
rs4132601 | Codominant | T/T | 43% | 51% | – | 1.00 (Reference) | – | – | 1.00 (Reference) |
T/G | 43% | 45% | 0.60 | 1.15 (0.67–1.96) | 0,58 | 0.696 | 1.16 (0.68–1.99) | ||
G/G | 14% | 4% | 0.006 | 4.07 (1.40–11.79) | 0,009 | 0.027 | 4.21 (1.42–12.44) | ||
Dominant | TT vs. TG + G/G | 43.2 vs.56.8% | 51.3 vs.48.7% | 0.19 | 1.40 (0.84–2.34) | 0.19 | 0.285 | 1.41 (0.84–2.36) | |
Recessive | TT + TG vs. G/G | 86.4% vs.13.6% | 95.8)vs. 4.2% | 0.0059 | 3.80 (1.35–10.67) | 0.006 | 0.027 | 3.91 (1.37–11.19) | |
Over-dominant | T/T + G/G vs. T/G | 56.8 vs.43.2% | 55.5vs.44.5% | 0.79 | 0.93 (0.56–1.56) | 0.83 | 0.830 | 0.95 (0.56–1.58) | |
Additive | – | – | – | 0.027 | 1.56 (1.05–2.34) | 0.027 | 0.054 | 1.58 (1.05–2.37) | |
rs11978267 | Codominant | A/A | 75% | 81% | – | 1.00 (Reference) | – | – | 1.00 (Reference) |
A/G | 16% | 14% | 0.56 | 1.23(0.59–2.55) | 0,49 | 0.588 | 1.29 (0,61–2.70) | ||
G/G | 9% | 5% | 0.15 | 2.20 (0.75–6.43) | 0,16 | 0.30 | 2.16 (0.73–6.37) | ||
Dominant | A/A vs. A/G + G/G | 74.8 vs.25.2% | 81.5% vs.18.5% | 0.23 | 1.47 (0.78–2.75) | 0.2 | 0.30 | 1.51 (0.80–2.85) | |
Recessive | A/A + A/G vs. G/G | 90.9% vs.9.1% | 95.6 vs.4.4% | 0.16 | 2.13 (0.73–6.18) | 0.18 | 0.30 | 2.08 (0.71–6.10) | |
Over-dominant | A/A-G/G vs. A/G | 83.8% vs.16.2% | 85.9 vs.14.1% | 0.68 | 1.16 (0.56–2.39) | 0.59 | 0.59 | 1.22 (0.59–2.55) | |
Additive | – | – | – | 0.15 | 1.40 (0.89–2.19) | 0.14 | 0.30 | 1.41 (0.89–2.22) |