Table 1 Allele and genotype frequencies of UGT1A1 promoter polymorphisms among participants
Variables | SCA (N = 101) | AS (N = 19) | AA (N = 45) |
|---|---|---|---|
Freq n (%) | Freq n (%) | Freq n (%) | |
Allelotypes | |||
 (TA) 5 | 18 (11.7) | 2 (6.7) | 10 (12.5) |
 (TA)6 | 67 (43.5) | 16 (53.3) | 28 (35.0) |
 (TA)7 | 61 (39.6) | 10 (33.3) | 37 (46.2) |
 (TA)8 | 8 (5.2) | 2 (6.7) | 5 (6.3) |
UGT1A1 Genotypes | |||
 TA5/5 | 0 (0) | 0 (0) | 1 (2.2) |
 TA5/6 | 9 (8.9) | 0 (0) | 1 (2.2) |
 TA5/7 | 6 (6.0) | 1 (5.2) | 8 (17.7) |
 TA5/8 | 3 (2.9) | 0 (0) | 0 (0) |
 TA6/6 | 25 (24.7) | 8 (42.1) | 5 (11.1) |
 TA6/7 | 31 (30.7) | 7 (36.8) | 21 (46.7) |
 TA6/8 | 2 (2.0) | 1 (5.2) | 1 (2.2) |
 TA7/7 | 22 (21.7) | 1 (5.2) | 4 (8.9) |
 TA7/8 | 2 (2.0) | 1 (5.2) | 4 (8.9) |
 TA8/8 | 1 (1.0) | 0 (0) | 0 (0) |
UGT1A1 Genotypes by degree of Activity | |||
 Low-Activity genotypes TA (7/7, 7/8, 8/8) | 25 (24.8) | 2 (10.5) | 8 (17.8) |
 Intermediate-Activity genotypes (TA6/7, TA6/8), TA5/7, TA5/8, | 42 (41.5) | 9 (47.4) | 30 (66.7) |
 Normal Activity genotypes i.e. (Wild Type) TA6/6 | 25 (24.8) | 8 (42.1) | 5 (11.1) |
 High-Activity genotypes TA5/5, TA5/6, | 9 (8.9) | 0 (0) | 2 (4.4) |