Table 2 Meta-analysis of the association of hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism with renal cancer and prostate cancer
Cancer Type | Group and subgroups | Studies Number | Q test P-value | Model selected | OR (95%CI) | P |
|---|---|---|---|---|---|---|
Renal cancer | ||||||
G vs A | Overall | 4 | <0.00001 | Random | 0.65 (0.26,1.67) | 0.38 |
Caucasian | 3 | 0.0004 | Random | 0.61 (0.16,2.30) | 0.46 | |
Asian | 1 | – | Fixed | 0.86 (0.55,1.33) | 0.49 | |
AA vs AG + GG | Overall | 4 | 0.76 | Fixed | 3.09 (1.38,6.92) | 0.006 |
Caucasian | 3 | 0.76 | Fixed | 3.09 (1.38,6.92) | 0.006 | |
Asian | 1 | – | Fixed | – | – | |
GG vs AG + AA | Overall | 4 | <0.00001 | Random | 0.63 (0.20,2.03) | 0.44 |
Caucasian | 3 | <0.00001 | Random | 0.59 (0.11,3.31) | 0.55 | |
Asian | 1 | – | Fixed | 0.85 (0.55,1.33) | 0.48 | |
Prostate cancer | ||||||
G vs A | Overall | 4 | 0.49 | Fixed | 0.68 (0.47,0.99) | 0.04 |
Caucasian | 1 | – | Fixed | 0.67 (0.09,4.74) | 0.68 | |
Asian | 1 | – | Fixed | 0.58 (0.36,0.91) | 0.02 | |
AA vs AG + GG | Overall | 4 | – | Fixed | 3.25 (0.13,79.90) | 0.47 |
Caucasian | 1 | – | Fixed | – | – | |
Asian | 1 | – | Fixed | 3.25 (0.13,79.90) | 0.47 | |
GG vs AG + AA | Overall | 4 | 0.50 | Fixed | 0.69 (0.47,1.00) | 0.05 |
Caucasian | 1 | – | Fixed | 0.66 (0.09,4.76) | 0.68 | |
Asian | 1 | – | Fixed | 0.58 (0.36,0.92) | 0.02 | |