Fig. 1

The variant distributions of NPHS1 in the domains of nephrin protein. Nephrin protein consists of a C-terminal cytoplasmic domain (blue curled line-C), a transmembrane domain (purple rectangle, TM), a fibronectin type III-like module (blue rhombus, FNIII), eight extracellular Ig-like domains (pink oval, Ig 1–8) and a signal peptide domain (blue curled line-N). All amino acid changes found in this study were listed. The orange boxes indicate the synonymous mutations for the corresponding protein domains. The blue boxes indicate the missense mutations for the corresponding protein domains. Red bold font indicates the strong susceptibility to mutations