The association between interleukin-6 gene -174G/C single nucleotide polymorphism and sepsis: an updated meta-analysis with trial sequential analysis

Chen, Yao; Hu, Yanyan; Song, Zhenju

doi:10.1186/s12881-019-0766-2

Table 1 Main characteristics of the included studies

From: The association between interleukin-6 gene -174G/C single nucleotide polymorphism and sepsis: an updated meta-analysis with trial sequential analysis

First author	Year	Country	Age group	Type of case	Type of control	Ethnicity	Case			Control			HWE^a in control
First author	Year	Country	Age group	Type of case	Type of control	Ethnicity	GG	GC	CC	GG	GC	CC	HWE^a in control
Schluter B	2002	USA	Adult	Sepsis, severe sepsis	Healthy	Caucasian	25	46	24	71	94	42	Yes
Schluter B	2002	USA	Adult	Non-survivor	Survivor	Caucasian	2	17	6	11	8	6	Yes
Harding D	2003	UK	Infant	Septicemia	Preterm infant	Mainly Caucasian	24	27^b		30	76^b		N/A
Balding J	2003	Ireland	Adult	Meningococcal sepsis	Healthy	Caucasian	59	97	27	123	209	68	Yes
Balding J	2003	Ireland	Adult	Non-survivor	Survivor	Caucasian	13	10	2	46	87	25	Yes
Treszl A	2003	Hungary	Neonate	Sepsis	VLBW^c neonate	Caucasian	18	13	2	34	29	7	Yes
Barber RC	2004	USA	Adult	Severe sepsis	ICU patients with no or mild sepsis	Mixed	17	19^b		69	54^b		N/A
Ahrens P	2004	Germany	Infant	Sepsis	VLBW^c infants	Caucasian	24	21	5	97	177	32	No
Michalek J	2006	Czech Republic	aged 0–19 years	SIRS^d, sepsis, severe sepsis, septic shock and MODS^e	Healthy	Caucasian	103	172	48	160	345	139	Yes
McDaniel DO	2006	USA	not clear^f	Sepsis	ICU patients	African American	16^g		0	6^g		0	N/A
McDaniel DO	2006	USA	not clear^f	Sepsis	ICU patients	Caucasian	12^g		3	13^g		8	N/A
Sipahi T	2006	Turkey	aged 0–15 years	Severe sepsis	Healthy	not clear	26	14	4	52	19	6	No
Sipahi T	2006	Turkey	aged 0–15 years	Non-survivor	Survivor	not clear	9	5	1	17	9	3	Yes
Baier RJ	2006	USA	Infant	Sepsis	VLBW^c infant	African American	94	18	2	110	9	0	Yes
				Sepsis	VLBW^c infant	Caucasian	12	16	3	7	16	3	Yes
				Non-survivor	Survivor	African American	10	1	0	84	17	2	Yes
				Non-survivor	Survivor	Caucasian	1	1	1	11	15	2	Yes
Göpel W	2006	Germany	Infant	Sepsis	VLBW^c infant	Mainly Caucasian	29	50	18	128	143	49	Yes
Sabeinikovs O	2008	Latvia	Infant	Non-survivor	Survivor	Caucasian	10	21	13	20	32	7	Yes
Abdel-Hady H	2009	Egypt	Neonate	Sepsis	Neonates investigated for neonatal hyperbilirubinemia	Caucasian	17	26	11	28	32	11	Yes
Abdel-Hady H	2009	Egypt	Neonate	Non-survivor	Survivor	Caucasian	2	5	6	15	21	5	Yes
Solé-Violán J	2010	Spain	Adult	Severe sepsis and septic shock	CAP^h	Caucasian	141	144	36	392	341	84	Yes
Davis SM	2010	USA	Female adult	Puerperal group streptococcus sepsis	Healthy	Caucasian	10	11	2	21	22	9	Yes
Carregaro F	2011	Brazil	Adult	Sepsis, severe sepsis and septic shock	Healthy	Mainly Caucasianⁱ	49	39	9	94	96	17	Yes
Accardo Palumbo A	2011	Italy	aged 13–82 years	Sepsis	Burned patient	not clear	14^g		2	22^g		4	N/A
Watanabe E	2012	USA	Adult	Non-survivor	Survivor	Caucasian	113	149	46	245	363	125	Yes
Martín-Loeches I	2012	Spain	Adult	Sepsis, severe sepsis and septic shock	Healthy	Caucasian	581	516	130	438	413	102	Yes
Feng B	2015	China	Adult	Non-survivor	Survivor	Asian	42	20	1	139	72	3	Yes
Allam G	2015	Saudi Arabia	Infant	Early-onset sepsis	Healthy	not clear	39	20	10	13	32	23	Yes
Lorente L	2016	Spain	Adult	Non-survivor	Survivor	not clear	47	36	3	76	74	27	Yes
Mao ZR	2016	China	Adult	Sepsis	Healthy	Asian	56	37	95	97	66	37	No
Jimenez-Sousa MA	2017	Spain	Adult	Septic shock	Healthy	Not clear	93	90	19	43	51	13	Yes

^aHardy-Weinberg equilibrium
^bGC and CC
^cvery low birth weight
^dsystemic inflammatory response syndrome
^emultiple organ disorder syndrome
^fpatients in surgery intensive care unit
^gGG and GC
^hcommunity-acquired pneumonia
ⁱCaucasian ancestry mainly, together with small amount of Asian and African ancestry

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