Association study between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and metabolic syndrome

Tremblay, Monique; Brisson, Diane; Gaudet, Daniel

doi:10.1186/s12881-018-0641-6

Table 1 Subjects’ characteristics according to the SST poly T repeat polymorphism genotype in the entire sample and according to gender

From: Association study between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and metabolic syndrome

All subjects Genotype	13/13			13/14			13/15			13/16			p	p*
n	913			69			571			172
Gender M/W %	52.0/48.0			55.1/44.9			50.6/49.4			57.6/42.4			0.42
Age (years)	49.7	±	11.8	47.4	±	11.7	50.1	±	12.2	50.3	±	12.1	0.33
CT (mmol/l)	5.96	±	1.60	6.01	±	1.85	6.00	±	1.68	6.33	±	2.01a	0.07	0.06
HDL-C (mmol/l)	1.20	±	0.45	1.14	±	0.41	1.20	±	0.47	1.11	±	0.44	0.07	0.17
LDL(mmol/l)	3.66	±	1.47	3.70	±	1.33	3.59	±	1.25	3.74	±	1.62	0.63	0.71
TG (mmol/l) ^a	1.80	±	2.22	1.89	±	2.26	1.90	±	2.12	2.19	±	3.11 a	0.007	0.01
WG (cm)	90.1	±	13.1	92.3	±	13.5	90.6	±	13.0	94.0	±	13.6 ac	0.004	0.009
BMI (kg/m²)	26.8	±	4.5	28.0	±	5.0	27.0	±	4.5	28.0	±	4.5 ac	0.002	0.003
Glycaemia (mmol/l) ^a	5.58	±	1.49	5.87	±	1.75	5.67	±	1.68	5.82	±	1.56	0.06	0.05
Systolic BP (mmHg)	124.9	±	19.4	122.2	±	15.9	128.5	±	20.5	131.1	±	22.5 ab	0.001	< 0.001
Diastolic BP (mmHg)	78.4	±	11.5	79.0	±	10.9	79.2	±	11.1	80.9	±	11.4 a	0.05	0.08
FFA (mmol/l) ^a	0.49	±	0.25	0.45	±	0.24	0.50	±	0.33	0.53	±	0.28	0.14	0.12
Glycerol (mmol/l) ^a	0.07	±	0.09	0.06	±	0.03	0.07	±	0.28	0.07	±	0.06	0.52	0.28
Men
Genotype	13/13			13/14			13/15			13/16			p	p**
n	475			38			289			99
Age (years)	49.4	±	11.2	48.2	±	11.2	48.8	±	11.7	49.9	±	11.4	0.74
CT (mmol/l)	5.93	±	1.57	6.17	±	1.43	5.98	±	1.61	6.35	±	2.14	0.12	0.106
HDL-C (mmol/l)	1.04	±	0.34	1.01	±	0.33	1.02	±	0.31	0.94	±	0.28 a	0.036	0.034
LDL(mmol/l)	3.73	±	1.46	4.03	±	1.50	3.73	±	1.30	3.79	±	1.71	0.67	0.68
TG (mmol/l) ^a	1.90	±	2.30	2.08	±	2.29	2.00	±	2.12	2.44	±	3.61 a	0.009	0.008
WG (cm)	96.3	±	10.4	96.8	±	11.4	96.1	±	11.0	99.1	±	11.5	0.09	0.10
BMI (kg/m²)	27.4	±	3.9	28.1	±	4.2	27.4	±	4.0	28.2	±	4.1	0.23	0.22
Glycaemia (mmol/l) ^a	5.77	±	1.64	6.31	±	2.12	5.74	±	1.48	5.87	±	1.31	0.11	0.09
Systolic BP (mmHg)	125.6	±	17.0	121.9	±	17.9	127.3	±	18.9	127.7	±	18.5	0.17	0.19
Diastolic BP (mmHg)	80.1	±	11.1	79.2	±	11.3	79.4	±	10.4	80.6	±	10.9	0.73	0.78
FFA (mmol/l) ^a	0.43	±	0.24	0.40	±	0.24	0.46	±	0.29	0.49	±	0.27	0.07	0.17
Glycerol (mmol/l) ^a	0.06	±	0.07	0.06	±	0.03	0.10	±	0.38	0.07	±	0.06	0.37	0.39
Women
Genotype	13/13			13/14			13/15			13/16			p	p**
n	438			31			282			73
Age (years)	50.1	±	12.4	46.5	±	12.3	51.4	±	12.7	50.9	±	13.0	0.16
CT (mmol/l)	5.99	±	1.63	5.82	±	2.27	6.02	±	1.76	6.31	±	1.83	0.45	0.49
HDL-C (mmol/l)	1.37	±	0.48	1.31	±	0.44	1.38	±	0.53	1.34	±	0.51	0.83	0.88
LDL(mmol/l)	3.57	±	1.48	3.30	±	0.96	3.44	±	1.17	3.67	±	1.50	0.37	0.37
TG (mmol/l) ^a	1.69	±	2.11	1.68	±	2.23	1.80	±	2.12	1.88	±	2.15	0.49	0.63
WG (cm)	83.5	±	12.6	86.7	±	13.9	85.0	±	12.4	87.0	±	13.2	0.07	0.05
BMI (kg/m²)	26.1	±	4.9	27.9	±	6.0	26.5	±	4.8	27.7	±	5.1	0.019	0.013
Glycaemia (mmol/l) ^a	5.37	±	1.28	5.34	±	0.91	5.60	±	1.87	5.74	±	1.86	0.13	0.16
Systolic BP (mmHg)	124.1	±	21.7	122.6	±	13.4	129.7	±	22.0a	135.8	±	26.5 a	< 0.001	< 0.001
Diastolic BP (mmHg)	76.5	±	11.6	78.7	±	10.5	78.9	±	11.8	81.3	±	12.2 a	0.003	0.003
FFA (mmol/l) ^a	0.57	±	0.26	0.53	±	0.23	0.55	±	0.36	0.60	±	0.29	0.42	0.66
Glycerol (mmol/l) ^a	0.09	±	0.11	0.08	±	0.03	0.08	±	0.08	0.09	±	0.05	0.28	0.13

All data are mean ± Standard deviation
Significantly different (p < 0.05) as compared to (a) 13/13; (b) to 13/14; (c) to 13/15
Significant p-value are in bold
CT cholesterol total, HDL-C high density lipoprotein-cholesterol, LDL-C light density lipoprotein-cholesterol, TG triglycerides, WG Waist girth, BP blood pressure, BMI body mass index, FFA free fatty acid
*age and gender included as a covariates
**age included as a covariate
^a= geometrical mean and p-value obtained after log₁₀ transformation

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