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Table 5 Characteristics of studies included in the meta-analysis

From: Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies

Author Year Country Ethnicity Disease type Genotyping Source of controls Alcohol-dependence (n) Controls (n) P for HWE Quality
Total AA AG GG Total AA AG GG
Bergen et al. 1997 USA Caucasian Alcohol-dependence Direct sequencing and PCR-RFLP Population-based 160 123 35 2 264 204 59 1 0.1285 7
Sander et al. 1998 German Caucasian Alcohol-dependence PCR-RFLP Population-based 327 261 62 4 340 289 49 2 0.9606 6
Franke et al. 2001 German Caucasian Alcohol-dependence Direct sequencing and PCR-RFLP Mixed 221 170 50 1 365 284 74 7 0.4024 8
Schinka et al. 2002 USA Caucasian Alcohol-dependence Puregeneā„¢ kit or standard phenol-chloroform method Population-based 179 152 27 0 297 220 73 4 0.4531 7
Kim et al. 2004 Korea Asian Alcohol-dependence PCR-RFLP Hospital-based 100 46 47 7 128 54 53 21 0.2014 8
Kim et al. 2004 Korea Asian Alcohol-dependence PCR-RFLP Hospital-based 112 37 61 14 140 68 57 15 0.5582 7
Loh et al. 2004 China Taiwan Asian Alcohol-dependence PCR-RFLP Mixed 154 59 77 18 146 70 56 20 0.1136 8
Bart et al. 2005 USA Caucasian Alcohol-dependence PCR-RFLP Population-based 389 299 90 170 147 23 Not available 8
Nishizawa et al. 2006 Japan Asian Alcohol-dependence PCR-RFLP Population-based 64 12 37 15 74 26 33 15 0.4493 8
Zhang et al. 2006 USA and Russia Caucasian Alcohol-dependence PCR-RFLP Mixed 318 246 68 4 338 256 78 4 0.4713 7
Deb et al. 2010 India Asian Alcohol-dependence PCR-RFLP Mixed 53 16 32 5 82 44 30 8 0.3967 8
Miranda et al. 2010 USA Caucasian Alcohol-dependence TaqMan assays Population-based 27 13 14 160 134 26 > 0.05 8
Dou et al. 2011 China Asian Alcohol-dependence PCR-RFLP Population-based 118 48 53 17 218 74 110 34 0.5127 6
Koller et al. 2012 Germany Caucasian Alcohol-dependence Fluorescence resonance energy transfer method Hospital-based 1845 1461 353 31 1863 1417 419 27 0.5275 9
Huang et al. 2012 China Asian Alcohol-dependence PCR-RFLP Population-based 45 33 11 1 45 33 12 0 0.3021 6
Francesc 2015 Spain Caucasian Alcohol-dependence PCR-RFLP Population-based 630 425 190 15 133 101 30 2 0.893 7
Jin 2015 China Asian Alcohol-dependence PCR-RFLP Population-based 58 41 12 5 50 39 9 2 0.1487 7