Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies

Kong, Xiangyi; Deng, Hao; Gong, Shun; Alston, Theodore; Kong, Yanguo; Wang, Jingping

doi:10.1186/s12881-017-0478-4

Table 5 Characteristics of studies included in the meta-analysis

From: Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies

Author	Year	Country	Ethnicity	Disease type	Genotyping	Source of controls	Alcohol-dependence (n)				Controls (n)				P for HWE	Quality
Author	Year	Country	Ethnicity	Disease type	Genotyping	Source of controls	Total	AA	AG	GG	Total	AA	AG	GG	P for HWE	Quality
Bergen et al.	1997	USA	Caucasian	Alcohol-dependence	Direct sequencing and PCR-RFLP	Population-based	160	123	35	2	264	204	59	1	0.1285	7
Sander et al.	1998	German	Caucasian	Alcohol-dependence	PCR-RFLP	Population-based	327	261	62	4	340	289	49	2	0.9606	6
Franke et al.	2001	German	Caucasian	Alcohol-dependence	Direct sequencing and PCR-RFLP	Mixed	221	170	50	1	365	284	74	7	0.4024	8
Schinka et al.	2002	USA	Caucasian	Alcohol-dependence	Puregene™ kit or standard phenol-chloroform method	Population-based	179	152	27	0	297	220	73	4	0.4531	7
Kim et al.	2004	Korea	Asian	Alcohol-dependence	PCR-RFLP	Hospital-based	100	46	47	7	128	54	53	21	0.2014	8
Kim et al.	2004	Korea	Asian	Alcohol-dependence	PCR-RFLP	Hospital-based	112	37	61	14	140	68	57	15	0.5582	7
Loh et al.	2004	China Taiwan	Asian	Alcohol-dependence	PCR-RFLP	Mixed	154	59	77	18	146	70	56	20	0.1136	8
Bart et al.	2005	USA	Caucasian	Alcohol-dependence	PCR-RFLP	Population-based	389	299	90		170	147	23		Not available	8
Nishizawa et al.	2006	Japan	Asian	Alcohol-dependence	PCR-RFLP	Population-based	64	12	37	15	74	26	33	15	0.4493	8
Zhang et al.	2006	USA and Russia	Caucasian	Alcohol-dependence	PCR-RFLP	Mixed	318	246	68	4	338	256	78	4	0.4713	7
Deb et al.	2010	India	Asian	Alcohol-dependence	PCR-RFLP	Mixed	53	16	32	5	82	44	30	8	0.3967	8
Miranda et al.	2010	USA	Caucasian	Alcohol-dependence	TaqMan assays	Population-based	27	13	14		160	134	26		> 0.05	8
Dou et al.	2011	China	Asian	Alcohol-dependence	PCR-RFLP	Population-based	118	48	53	17	218	74	110	34	0.5127	6
Koller et al.	2012	Germany	Caucasian	Alcohol-dependence	Fluorescence resonance energy transfer method	Hospital-based	1845	1461	353	31	1863	1417	419	27	0.5275	9
Huang et al.	2012	China	Asian	Alcohol-dependence	PCR-RFLP	Population-based	45	33	11	1	45	33	12	0	0.3021	6
Francesc	2015	Spain	Caucasian	Alcohol-dependence	PCR-RFLP	Population-based	630	425	190	15	133	101	30	2	0.893	7
Jin	2015	China	Asian	Alcohol-dependence	PCR-RFLP	Population-based	58	41	12	5	50	39	9	2	0.1487	7

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