Fig. 2

Light and electron microscopic findings of renal biopsies from patients 1 and 2. a On microscopic examination of patient 1, there are some vague vacuolizations of podocytes (black arrowhead), although he showed normal renal function and proteinuria (H&E stain, ×400). b Multilamellated myelin figures (white arrowhead), so-called zebra bodies—which are typical findings in Fabry disease—are found in patient 1’s podocytes on electron microscopy. c Similar vacuolated epithelial cells (black arrowhead) are found in the relatively preserved glomerulus of patient 2, whereas most glomeruli are damaged by sclerosis (H&E stain, ×400). d A focal area showing a tiny, dark–stained, round multilamellar inclusion (white arrowhead) on the electron microscopy result for patient 2