Table 1 Distribution of anthropometric and metabolic variables according to Framingham Risk Score
From: Association between global leukocyte DNA methylation and cardiovascular risk in postmenopausal women
Characteristic | Overall (n = 90) | FRS <10 % (n = 69) | FRS ≥10 % (n = 21) | p* |
|---|---|---|---|---|
Age (years) | 55.5 ± 4.9 | 54.4 ± 4.4 | 59.1 ± 4.6 | 0.001 |
Time since menopause (years) | 5.8 (3.0 – 10.0) | 5.0 (2.5 – 9.0) | 10 (4.0 – 13.2) | 0.004 |
BMI (kg/m2) | 27.2 ± 4.6 | 26.9 ± 4.7 | 28.0 ± 4.3 | 0.34 |
SBP (mmHg) | 127.5 ± 17.3 | 120.6 ± 11.2 | 150.8 ± 13.5 | 0.001 |
DBP (mmHg) | 78.9 ± 10.1 | 76.4 ± 9.2 | 87.3 ± 8.6 | 0.001 |
Fasting glucose (mg/dL) | 93.3 ± 8.9 | 93.6 ± 9.1 | 92.1 ± 8.0 | 0.47 |
Total cholesterol (mg/dL) | 216.5 ± 33.8 | 212.3 ± 32.7 | 231.0 ± 34.4 | 0.02 |
LDL-c (mg/dL) | 139.2 ± 28.8 | 135.3 ± 27.3 | 152.8 ± 30.2 | 0.01 |
HDL-c (mg/dL) | 53.9 ± 12.7 | 53.4 ± 13.2 | 55.5 ± 10.7 | 0.49 |
Triglycerides (mg/dL) | 93.0 (72.0 – 139.7) | 91.0 (70.0 – 141.2) | 105.5 (75.2 – 141.0) | 0.87 |
HOMA-IR | 1.92 (1.30 – 3.19) | 1.9 (1.3 – 3.2) | 1.9 (1.2 – 2.9) | 0.68 |
hs-CRP (mg/L) | 1.30 (0.37 – 3.66) | 1.0 (0.3 – 3.3) | 2.5 (0.5 – 5.5) | 0.27 |
Estradiol (pg/mL) | 20.4 (12.0 – 31.0) | 20.3 (12.0 – 31.5) | 22.4 (13.4 – 30.8) | 0.92 |
Global DNA methylation (% 5 mC) | 26.5 (23.6 – 36.9) |  |  |  |