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Table 4 Frequencies of the most common microsatellite alleles of the BRCA2 region in mutated probands and controls

From: Tracking of the origin of recurrent mutations of the BRCA1 and BRCA2 genes in the North-East of Italy and improved mutation analysis strategy

  Markersa
D13S220 D13S267 D13S171 D13S1701 D13S1698 D13S260 D13S290 D13S1246
35169554 34264119 33253912 33144530 32704522 32436758 31429174 31105437
187–203 144–160 226–242 283–311 151–179 154–172 174–192 191–211
c.5682C > G Alleles b 189 156 226 299 155 162 174 201
  Cases (10)c 5 (0.5) 3 (0.3) 5 (0.5) 6 (0.6) 6 (0.6) 5 (0.5) 7 (0.7) 4 (0.4)
  Controls (142–182)c 59 (0.42) 38 (0.22) 40 (0.22) 51 (0.29) 46 (0.25) 19 (0.11) 105 (0.6) 26 (0.14)
  P valued n.s. n.s. n.s. n.s. <0.05 <0.01 n.s. n.s.
c.7806-2A > G Alleles b 199 144 230 299 155 160 174 205
  Cases (26)c 10 (0.38) 19 (0.73) 18 (0.69) 16 (0.62) 16 (0.62) 14 (0.54) 20 (0.77) 9 (0.35)
  Controls (142–182)c 34 (0.24) 68 (0.40) 73 (0.41) 51 (0.29) 46 (0.25) 28 (0.16) 105 (0.6) 60 (0.33)
  P valued n.s. <0.01 <0.02 <0.01 <0.01 <0.01 n.s. n.s.
c.8878C > T Alleles b 189 144 240 287 173 168 174 199
  Cases (10)c 4 (0.4) 5 (0.5) 7 (0.7) 5 (0.5) 5 (0.5) 4 (0.4) 8 (0.8) 4 (0.4)
  Controls (142–182)c 34 (0.24) 68 (0.4) 61 (0.34) 22 (0.12) 4 (0.02) 28 (0.16) 105 (0.6) 32 (0.18)
  P valued n.s. n.s. <0.05 <0.01 <0.01 n.s. n.s. n.s.
  1. aPhysical map positions on chromosome 13 based on Genome Reference Consortium Human Build 37 (GRCh37) [47] and allele size ranges are indicated for each locus
  2. bThe most frequent allele of the cases is reported for each locus. Alleles showing statistically significant association (corrected P value < 0.05) are underlined
  3. cTotal number of case and control chromosomes in parentheses. Number of chromosomes carrying the indicated alleles are reported for each locus, along with the allele frequency in parentheses
  4. dn.s. not significant