Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis

Wang, Shaoshuai; Sun, Haiying; Jia, Yao; Tang, Fangxu; Zhou, Hang; Li, Xiong; Zhou, Jin; Huang, Kecheng; Zhang, Qinghua; Hu, Ting; Yang, Ru; Wang, Changyu; Xi, Ling; Deng, Dongrui; Wang, Hui; Wang, Shixuan; Ma, Ding; Li, Shuang

doi:10.1186/s12881-015-0168-z

BMC Medical Genetics

Table 5 Meta-analysis results of subgroups

From: Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis

Gene symbol	Subgroup	Comparison	No.	Q-P	Model	OR 95% CI	P
GSTT1	Total	postive/null	15	<0.00001	Random	0.69[0.60,0.79]	0.03
	Caucasians	postive/null	3	0.99	Fixed	0.89[0.69,1.30]	0.54
	Asian	postive/null	10	<0.00001	Random	0.80[0.56,1.14]	0.22
GSTM1	Total	postive/null	16	<0.00001	Random	0.70[0.53,0.92]	0.01
	Caucasians	postive/null	6	<0.00001	Random	0.51[0.25,1.03]	0.06
	Asian	postive/null	10	<0.00001	Random	0.79[0.60,1.02]	0.07
P53 codon 72	Total	C/G	44	<0.00001	Random	1.14[0.99,1.34]	0.07
	Caucasians	C/G	11	0.02	Fixed	1.14[1.02,1.27]	0.02
	Asian	C/G	17	<0.00001	Random	1.20[0.92,1.58]	0.18
	Total	CC + GC/GG	44	<0.0001	Random	1.06[0.90,1.23]	0.57
	Caucasians	CC + GC/GG	11	0.49	Fixed	1.02[0.82,1.28]	0.83
	Asian	CC + GC/GG	17	0.0009	Random	0.95[0.74,1.22]	0.70
	Total	CC/GC + GG	44	<0.00001	Random	1.18[0.96,1.42]	0.11
	Caucasians	CC/GC + GG	11	0.02	Fixed	1.26[1.08,1.46]	0.003
	Asian	CC/GC + GG	17	<0.00001	Random	1.24[0.92,1.67]	0.15
TNF-α-308	Total	G/A	15	<0.00001	Random	0.82[0.68,0.98]	0.03
	Caucasians	G/A	6	<0.00001	Random	0.83[0.61,1.13]	0.25
	Asian	G/A	5	0.0003	Random	0.72[0.45,1.17]	0.18
	Total	GG + GA/AA	15	<0.00001	Random	0.82[0.57,1.18]	0.28
	Caucasians	GG + GA/AA	6	<0.00001	Random	0.74[0.39,1.39]	0.35
	Asian	GG + GA/AA	5	0.09	Fixed	0.97[0.79,1.19]	0.76
	Total	GG/GA + AA	15	0.0004	Random	0.85[0.71,1.02]	0.08
	Caucasians	GG/GA + AA	6	0.003	Random	0.87[0.68,1.11]	0.27
	Asian	GG/GA + AA	5	0.002	Random	0.76[0.46,1.27]	0.29
XRCC1 Codon 399	Total	G/A	12	<0.00001	Random	1.23[0.80,1.91]	0.34
	Caucasians	G/A	3	0.004	Random	0.98[0.60,1.59]	0.92
	Asian	G/A	7	<0.00001	Random	1.45[0.83,2.53]	0.19
	Total	GG + GA/AA	11	<0.0001	Random	1.22[0.49,3.01]	0.67
	Caucasians	GG + GA/AA	3	0.46	Fixed	0.71[0.50,1.01]	0.06
	Asian	GG + GA/AA	7	<0.0001	Random	2.01[0.76,5.31]	0.16
	Total	GG/GA + AA	12	<0.0001	Random	1.18[0.84,1.64]	0.33
	Caucasians	GG/GA + AA	4	0.001	Random	1.13[0.56,2.29]	0.74
	Asian	GG/GA + AA	7	<0.0001	Random	1.31[0.88,1.95]	0.18

No, number of studies; OR, combined odds ratio; CI, confidence interval; P, P value.

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