Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis

Wang, Shaoshuai; Sun, Haiying; Jia, Yao; Tang, Fangxu; Zhou, Hang; Li, Xiong; Zhou, Jin; Huang, Kecheng; Zhang, Qinghua; Hu, Ting; Yang, Ru; Wang, Changyu; Xi, Ling; Deng, Dongrui; Wang, Hui; Wang, Shixuan; Ma, Ding; Li, Shuang

doi:10.1186/s12881-015-0168-z

BMC Medical Genetics

Table 2 Meta-analysis results under the dominant genetic model

From: Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis

SNP	Comparison	Gene symbol	No.	Q	Q-P	I ²	Model	95% CI	P
rs1048943	GG + GA/AA	CYP1A1 A4889G	8	8.8	0.12	0.43	Fixed	0.40[0.25,0.66]	0.0002
rs11134527	AA + AG/GG	pri-miR-218	2	0	0.98	0	Fixed	1.25[1.06,1.47]	0.007
rs2279744	TT + TG/GG	MDM2	2	3.32	0.07	0.7	Fixed	0.55[0.34,0.88]	0.01
rs4646903	CC + CT/TT	CYPA1 T6235C	8	33.12	<0.0001	0.79	Random	1.65[1.12,2.43]	0.01
rs1801275	AA + AG/GG	IL-4R	2	0.15	0.69	0	Fixed	1.70[1.07,2.68]	0.02
rs1800872	CC + AC/AA	IL-10 C592A	5	1.88	0.76	0	Fixed	0.79[0.63,0.98]	0.03
rs62559044	AA + AT/TT	IFN-r A874T	4	2.47	0.48	0	Fixed	1.58[1.15,2.15]	0.04
rs1800896	GG + GA/AA	IL-10 G1082A	8	9.96	0.13	0.4	Fixed	1.19[0.99,1.44]	0.06
rs1800795	GG + GC/CC	IL-6	3	4.46	0.11	0.55	Fixed	0.52[0.26,1.07]	0.08
rs1052134	Ser326Cys	OGG1	2	1.42	0.23	0.29	Fixed	1.59[0.93,2.72]	0.09
rs352140	GG + GA/AA	TLR9 G2848A	3	4.81	0.09	0.58	Fixed	1.25[0.95,1.63]	0.10
rs3212227	AA + AC/CC	IL-12B	2	2.03	0.15	0.51	Fixed	0.77[0.56,1.06]	0.11
rs833061	TT + TC/CC	VEGF T460C	2	1.33	0.25	0.25	Fixed	1.75[0.85,3.59]	0.13
rs1805087	AA + AG/GG	MTR A2756G	2	2.72	0.1	0.63	Fixed	1.64[0.83,3.27]	0.16
rs1801133	TT + TC/CC	MTHFRC677T	8	28.67	0.0002	0.76	Random	0.81[0.60,1.10]	0.17
rs5742909	TT + TC/CC	CTLA-318	5	19.13	0.0007	0.79	Random	1.43[0.86,2.39]	0.17
rs1800629	GG + GA/AA	TNF-α-308	15	52.19	<0.00001	0.75	Random	0.82[0.57,1.18]	0.28
rs187084	TT + TC/CC	TLR9T1486C	3	2.4	0.3	0.17	Fixed	0.88[0.71,1.11]	0.29
rs16944	CC + CT/TT	IL-1β	4	16.3	0.001	0.82	Random	0.76[0.45,1.28]	0.30
rs568408	GG + GA/AA	IL-12A	2	0.64	0.42	0	Fixed	0.79[0.46,1.35]	0.39
rs1800682	GG + GA/AA	Fas	9	63.31	<0.00001	0.87	Random	1.20[0.77,1.87]	0.41
rs763110	TT + TC/CC	FASL T844C	2	13.18	0.0003	0.92	Random	0.77[0.38,1.52]	0.45
rsl801270	CC + CA/AA	p21 codon 31	7	31.99	<0.0001	0.81	Random	0.83[0.51,1.35]	0.46
rs1799864	AA + GA/GG	CCR2	3	128	<0.0001	0.98	Random	1.65[0.35,7.82]	0.52
rs361525	GG + GA/AA	TNF-α-238	8	399	<0.0001	0.98	Random	1.98[0.24,16.2]	0.53
rs3116496	CC + CT/TT	CD28	3	17.6	0.0002	0.89	Random	1.14[0.69,1.88]	0.61
rs3021097	CC + CT/TT	IL-10 C819T	2	1.27	0.26	0.21	Fixed	1.05[0.73,1.49]	0.80
rs603965	GG + GA/AA	CCND1	6	4.24	0.52	0	Fixed	0.98[0.82,1.17]	0.80
rs1801131	AA + CA/CC	MTHFR A1298C	2	2.95	0.09	0.66	Fixed	1.07[0.63,1.81]	0.81
rs3025039	CC + CT/TT	VEGF C936T	2	2.28	0.13	0.56	Fixed	1.08[0.57,2.04]	0.82
rs5275	CC + CT/TT	COX-2	2	0.03	0.86	0	Fixed	0.98[0.73,1.32]	0.91
rs4404252	TT + TC/CC	ICOS T/C	2	0.02	0.88	0	Fixed	0.99[0.64,1.54]	0.98

No, number of studies; OR, combined odds ratio; CI, confidence interval; P, P value.

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