Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

Table 4 Haplotypes of the TLR2 and TLR4 genes and their distributions in the three groups

SNP marker	Haplotype	Frequency (No., %)			LTBI.vs.HC			PTB.vs.LTBI
SNP marker	Haplotype	HC ( n = 422)	LTBI ( n = 225)	PTB ( n = 109)	P	OR	95% CI	P	OR	95% CI
rs3804099	CC	183(21.7)	95(21.1)	52(23.8)	0.812	0.97	0.722-1.289	0.422	1.17	0.779-1.747
rs3804100	CT	185(21.9)	85(18.9)	36(16.5)	0.201	0.83	0.615-1.114	0.455	0.85	0.537-1.326
	TC	103(12.2)	56(12.4)	18(8.3)	0.900	1.02	0.709-1.465	0.106	0.63	0.341-1.129
	TT	373(44.2)	214(47.6)	112(51.4)	0.247	1.15	0.904-1.450	0.354	1.17	0.832-1.632
rs10759931	AT	376(44.4)	204(45.3)	136(62.4)	0.787	1.03	0.735-1.447	<0.001^a	2.00	1.221-3.289
rs10759932	GT	218(25.7)	112(24.9)	22(10.1)	0.712	0.95	0.642-1.401	<0.001^a	0.34	0.153-0.694
	GC	156(18.5)	88(19.6)	6(2.8)	0.639	1.07	0.693-1.646	<0.001^a	0.12	0.022-0.379
	AC	94(11.4)	46(10.2)	54(24.7)	0.614	0.91	0.511-1.578	<0.001^a	2.89	1.496-5.596
rs4986790	AC	644(76.3)	353(78.4)	157(72.0)	0.383	1.13	0.852-1.505	0.067	0.71	0.481-1.046
rs4986791	AT	49(5.8)	11(2.4)	18(8.3)	0.006	0.39	0.180-0.784	0.001^a	3.59	1.570-8.565
	GC	33(3.9)	9(2.0)	0(0)	0.065	0.50	0.209-1.083	-	-	-
	GT	118(14.0)	77(17.1)	43(19.7)	0.134	1.27	0.915-1.755	0.409	1.19	0.766-1.833

PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
^ap < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).

ISSN: 1471-2350