From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
Sweden PD-Goth | Italy | Sweden PD-Link | Malta | Poland | Germany | Meta-analysis 2 | |||
---|---|---|---|---|---|---|---|---|---|
SNP 1 | Genotype | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | p-value |
2 – rs7557529 | G > A | 0.9 (0.7 – 1.2) | 0.8 (0.7 – 1.0) | 1.2 (1.0 – 1.6) | 1.5 (1.1 – 2.0) | 1.3 (1.0 – 1.8) | 1.0 (0.6 – 1.7) | 1.08 (0.96 – 1.21) | 0.18 |
P1 – rs35652124 | A > G | 0.8 (0.6 – 1.2) | 0.7 (0.6 – 0.9) | 1.3 (1.0 – 1.7) | 0.9 (0.6 – 1.3) | 1.3 (1.0 – 1.8) | 1.1 (0.6 – 1.8) | 0.99 (0.87 – 1.12) | 0.86 |
P2 – rs6706649 | G > A | 0.9 (0.6 – 1.4) | 1.3 (0.9 – 1.8) | 1.1 (0.7 – 1.5) | 1.6 (1.0 – 2.4) | 1.0 (0.7 – 1.5) | 0.9 (0.4 – 2.0) | 1.14 (0.96 – 1.35) | 0.14 |
P3 – rs6721961 | C > A | 1.8 (1.1 – 3.0) | 1.1 (0.8 – 1.5) | 0.9 (0.6 – 1.4) | 0.7 (0.4 – 1.1) | 1.0 (0.7 – 1.6) | 1.3 (0.7 – 2.6) | 1.07 (0.90 – 1.27) | 0.45 |
3 – rs2886161 | A > G | 0.8 (0.6 – 1.2) | 0.7 (0.5 – 0.9) | 1.3 (1.0 – 1.7) | 1.0 (0.7 – 1.4) | 1.3 (1.0 – 1.8) | 1.1 (0.6 – 1.8) | 0.98 (0.87 – 1.12) | 0.81 |
4 – rs1806649 | G > A | 1.0 (0.7 – 1.3) | 1.2 (0.9 – 1.5) | 0.8 (0.6 – 1.1) | 0.8 (0.6 – 1.2) | 0.7 (0.5 – 0.9) | 0.7 (0.4 – 1.2) | 0.88 (0.77 – 1.01) | 0.07 |
5 – rs2001350 | A > G | 2.0 (1.1 – 3.6) | 1.3 (1.0 – 1.8) | 0.9 (0.6 – 1.3) | 0.8 (0.4 – 1.4) | 0.9 (0.6 – 1.4) | 1.0 (0.5 – 2.1) | 1.10 (0.91 – 1.34) | 0.31 |
6 – 10183914 | G > A | 0.8 (0.6 – 1.2) | 1.1 (0.9 – 1.4) | 0.8 (0.6 – 1.1) | 1.0 (0.7 – 1.4) | 0.8 (0.6 – 1.1) | 0.9 (0.6 – 1.6) | 0.93 (0.82 – 1.05) | 0.22 |