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Table 5 Individual SNP associations with risk of PD

From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study

   Sweden PD-Goth Italy Sweden PD-Link Malta Poland Germany Meta-analysis 2  
SNP 1 Genotype OR/allele (CI) OR/allele (CI) OR/allele (CI) OR/allele (CI) OR/allele (CI) OR/allele (CI) OR/allele (CI) p-value
2 – rs7557529 G > A 0.9 (0.7 – 1.2) 0.8 (0.7 – 1.0) 1.2 (1.0 – 1.6) 1.5 (1.1 – 2.0) 1.3 (1.0 – 1.8) 1.0 (0.6 – 1.7) 1.08 (0.96 – 1.21) 0.18
P1 – rs35652124 A > G 0.8 (0.6 – 1.2) 0.7 (0.6 – 0.9) 1.3 (1.0 – 1.7) 0.9 (0.6 – 1.3) 1.3 (1.0 – 1.8) 1.1 (0.6 – 1.8) 0.99 (0.87 – 1.12) 0.86
P2 – rs6706649 G > A 0.9 (0.6 – 1.4) 1.3 (0.9 – 1.8) 1.1 (0.7 – 1.5) 1.6 (1.0 – 2.4) 1.0 (0.7 – 1.5) 0.9 (0.4 – 2.0) 1.14 (0.96 – 1.35) 0.14
P3 – rs6721961 C > A 1.8 (1.1 – 3.0) 1.1 (0.8 – 1.5) 0.9 (0.6 – 1.4) 0.7 (0.4 – 1.1) 1.0 (0.7 – 1.6) 1.3 (0.7 – 2.6) 1.07 (0.90 – 1.27) 0.45
3 – rs2886161 A > G 0.8 (0.6 – 1.2) 0.7 (0.5 – 0.9) 1.3 (1.0 – 1.7) 1.0 (0.7 – 1.4) 1.3 (1.0 – 1.8) 1.1 (0.6 – 1.8) 0.98 (0.87 – 1.12) 0.81
4 – rs1806649 G > A 1.0 (0.7 – 1.3) 1.2 (0.9 – 1.5) 0.8 (0.6 – 1.1) 0.8 (0.6 – 1.2) 0.7 (0.5 – 0.9) 0.7 (0.4 – 1.2) 0.88 (0.77 – 1.01) 0.07
5 – rs2001350 A > G 2.0 (1.1 – 3.6) 1.3 (1.0 – 1.8) 0.9 (0.6 – 1.3) 0.8 (0.4 – 1.4) 0.9 (0.6 – 1.4) 1.0 (0.5 – 2.1) 1.10 (0.91 – 1.34) 0.31
6 – 10183914 G > A 0.8 (0.6 – 1.2) 1.1 (0.9 – 1.4) 0.8 (0.6 – 1.1) 1.0 (0.7 – 1.4) 0.8 (0.6 – 1.1) 0.9 (0.6 – 1.6) 0.93 (0.82 – 1.05) 0.22
  1. Odds ratios (OR) are given for the minor allele and presented as absolute numbers (95% CI). Sex was used as covariate for all materials except for Poland, where the number of males and females are identical in patients and controls.
  2. 1For SNP locations see Figure 1 and Table 2.
  3. 2The meta-analysis was calculated using inverse-variance weighting of effects with two-sided p-values, including all six materials.