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Table 3 Summary of the significant, false discovery rate adjusted, and cross-validated ADRA2C and ADRB1 polymorphism effects and interactions on age of onset, LVmass, LVEF, and heart failure survival

From: Multiple interactions between the alpha2C- and beta1-adrenergic receptors influence heart failure survival

ED (N = 655)

        
 

Age of Onset

LVMass Adj*

LVEF Adj**

Survival

 

SNP Main Effects

SNP-SNP Interaction

SNP Main Effects

SNP_SNP Interaction

SNP Main Effects

SNP_SNP Interaction

SNP Main Effects

SNP_SNP Interaction

Number of tests

22

209

22

200

22

204

22

231

P < 0.10

2

24

1

8

2

16

4

50

FDR (<0.30)

0

0

0

0

2

0

4

44

Cross Validation***

0

0

0

0

1

0

3

10

FDR and Cross-validation

0

0

0

0

1

0

2

6

  1. * LVMass was adjusted for age of onset, sex, height, weight, hypertension
  2. ** LVEF was adjusted for age of onset, sex
  3. *** For survival analysis, Risk Index was used to cross-validate, P-value for Cox model with Risk Index <0.1 is considered as crossvalidated. For continuous outcomes, 4-fold CV was used. Press-Rsquared >0.005 (SNP univ model) or Press-Rsquared for full model >0 and Press-Rsquared Difference between full model and submodel >0.005 (Epistasis) is considered to be crossvalidated for interaction.
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BMC Medical Genetics

ISSN: 1471-2350

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