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Figure 3 | BMC Medical Genetics

Figure 3

From: Array based characterization of a terminal deletion involving chromosome subband 15q26.2: an emerging syndrome associated with growth retardation, cardiac defects and developmental delay

Figure 3

Illustrative metaphase FISH images. The derivative chromosome is indicated with an arrow. A. Hybridization with a chromosome 15 specific WCP probe and a centromere 15 (CEP15) specific probe indicating that the derivative chromosome was entirely composed of chromosome 15-material and that it was dicentric. WCP15 cross-hybridizes with the p-arms of all acrocentric chromosomes (seen as green spots). B. Hybridization with a probe specific for the nucleolus organizing regions (NOR) of the acrocentric chromosomes and a control probe (15q14) showing the presence of p-arm material in duplicate on the derivative chromosome. C. Hybridization with BAC probes specific for the 15q11.2-q13.2 and 15q25.1-q26.1 regions showed that the corresponding target area was present in one copy on the derivative chromosome (left). Hybridization with BAC probes specific for the 15q26.2-15q26.3 region showed that the corresponding regions were lacking on the derivative chromosome (right).

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BMC Medical Genetics

ISSN: 1471-2350

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