Table 2 Detailed analysis for rs11102930, genotyped in 1120 and 869 controls.
From: Genomic NGFBvariation and multiple sclerosis in a case control study
Genotype (%) | p value | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP (maj./min. allele) | cohort | Stratif-ication | Maj. allele (%) | Min. allele (%) | p value | OR (CI*1) | XX | Xx | xx | Geno-type | Major allel dominant | co-dominant | Minor allele dominant | HWE p value | N |
rs11102930 (T/C) | MS | Ø | 1380 (64.3) | 766 (35.7) | 0.5414 | 0.959 (0.840–1.096) | 449 (41.8) | 482 (44.9) | 142 (13.2) | 0.6694 | 0.3713 | 0.7157 | 0.8148 | 0.48 | 1073 |
male | 423 (60.8) | 273 (39.2) | 0.0115 | 0.765 (0.622–0.942) | 124 (35.6) | 175 (50.3) | 49 (14.1) | 0.0259 | 0.2272 | 0.0664 | 0.0075 | 0.31 | 348 | ||
female | 957 (66.0) | 493 (34.0) | 0.2271 | 1.115 (0.934–1.332) | 325 (44.8) | 307 (42.3) | 93 (12.8) | 0.1682 | 0.8954 | 0.0695 | 0.0829 | 0.13 | 725 | ||
rr Ø | 764 (65.1) | 410 (34.9) | 0.9120 | 0.991 (0.848–1.158) | 251 (42.8) | 262 (44.6) | 74 (12.6) | 0.8773 | 0.6845 | 0.7010 | 0.9061 | 0.66 | 587 | ||
rr male | 212 (59.2) | 146 (40.8) | 0.0101 | 0.717 (0.557–0.924) | 59 (33.0) | 94 (52.5) | 26 (14.5) | 0.0206 | 0.2537 | 0.0465 | 0.0056 | 0.24 | 179 | ||
rr female | 552 (67.6) | 264 (32.4) | 0.0760 | 1.201 (0.981–1.472) | 192 (47.1) | 168 (41.2) | 48 (11.8) | 0.0872 | 0.7263 | 0.0525 | 0.0295 | 0.23 | 408 | ||
sp Ø | 303 (62.9) | 179 (37.1) | 0.3324 | 0.901 (0.731–1.112) | 97 (40.2) | 109 (45.2) | 35 (14.5) | 0.5288 | 0.2712 | 0.8855 | 0.5545 | 0.63 | 241 | ||
sp male | 78 (59.1) | 54 (40.9) | 0.0764 | 0.714 (0.491–1.036) | 23 (34.8) | 32 (48.5) | 11 (16.7) | 0.2125 | 0.2026 | 0.4665 | 0.1183 | 0.98 | 66 | ||
sp female | 225 (64.3) | 125 (35.7) | 0.7989 | 1.034 (0.798–1.341) | 74 (42.3) | 77 (44.0) | 24 (13.7) | 0.6875 | 0.7015 | 0.3886 | 0.5387 | 0.58 | 175 | ||
pp Ø | 313 (63.9) | 177 (36.1) | 0.5743 | 0.942 (0.764–1.161) | 101 (41.2) | 111 (45.3) | 33 (13.5) | 0.7926 | 0.5014 | 0.9019 | 0.7477 | 0.77 | 245 | ||
pp male | 133 (64.6) | 73 (35.4) | 0.5167 | 0.900 (0.655–1.237) | 42 (40.8) | 49 (47.6) | 12 (11.7) | 0.7250 | 0.8995 | 0.4775 | 0.4289 | 0.69 | 103 | ||
pp female | 180 (63.4) | 104 (36.6) | 0.9694 | 0.995 (0.753–1.314) | 59 (41.5) | 62 (43.7) | 21 (14.8) | 0.6352 | 0.4961 | 0.3850 | 0.6777 | 0.48 | 142 | ||
control | Ø | 1121 (65.3) | 597 (34.7) | 364 (42.4) | 393 (45.8) | 102 (11.9) | 0.79 | 859 | |||||||
male | 585 (66.9) | 289 (33.1) | 197 (45.1) | 191 (43.7) | 49 (11.2) | 0.79 | 437 | ||||||||
female | 536 (63.5) | 308 (36.5) | 167 (39.6) | 202 (47.9) | 53 (12.6) | 0.50 | 422 | ||||||||