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Table 2 Evolutionary conservation of the variant TSC2 amino acids. Inter-species conservation of the TSC2 S132, F143, A196, C244, Y598 I820, T993, L1511 and R1772 amino acids is shown.

From: Functional characterisation of the TSC1–TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex

Family 1    
  I820 R1772  
human PDII I KALP GQRK R LISS  
mouse PDII I KAL GQRK R LISS  
rat PDII I KAL GQRK R LISS  
pufferfish PDIM I KLL GQRK R LVST  
fruitfly PEALMRKLP no homology  
Family 2    
  T993 L1511  
human SRIQ T SLTS SVQL L DQI  
mouse SRIQ T SLTS SVQL L DQI  
rat SRIQ T SLTS SVQL L DQI  
pufferfish RRMH T STTT AVKV L DQM  
fruitfly no homology AVSLIDLVP  
Family 3    
  A196 Y598  
human DEYI A RM V IQLH Y KHSY  
mouse DEYI A SM V IQLH Y KHGY  
rat DEYI A PM V IQLH Y KHGY  
pufferfish DQNV A SM V LQLH Y KNKY  
fruitfly DKDILVGIV LELH Y ERPK  
Family 4    
  S132 F143 C244
human KDYP S NED RLEV F KALT IVTL C RTIN
mouse KDYP S NED RLEV F KALT IITL C RTIN
rat KDYP S NED RLEV F KALT IITL C RTVN
pufferfish RDYQPCNED RLEV F KALT IITL C RTVN
fruitfly IQNHEARED LLELLDTLT ITTL C RTVN