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Table 1 Phenotype List

From: Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

  

Exam cycle/s

  
 

N*

Offspring

Cohort

Adjustment

Covariates

Primary Phenotypes

Blood Pressure

SBP 1

2

1

12

Age and sex, multivariable

Cohort, sex, age, BMI

SBP 7

2

7

26

Age and sex, multivariable

Cohort, sex, age, BMI

SBP 1–7

2

Mean of exams 1–7

Mean of exams 12, 16, 18, 20, 22, 24, 26

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 1

2

1

12

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 7

2

7

26

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 1–7

2

Mean of exams 1–7

Mean of exams 12, 16, 18, 20, 22, 24, 26

Age and sex, multivariable

Cohort, sex, age, BMI

Tonometry

Carotid-femoral PWV

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

Carotid-brachial PWV

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

Forward pressure wave

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

Reflected pressure wave

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

Mean arterial pressure

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

Secondary Phenotypes^

Blood Pressure

DBP 2

2

2

16

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 3

2

3

18

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 4

2

4

20

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 5

2

5

22

Age and sex, multivariable

Cohort, sex, age, BMI

DBP 6

2

6

24

Age and sex, multivariable

Cohort, sex, age, BMI

SBP 2

2

2

16

Age and sex, multivariable

Cohort, sex, age, BMI

SBP 3

2

3

18

Age and sex, multivariable

Cohort, sex, age, BMI

SBP4

2

4

20

Age and sex, multivariable

Cohort, sex, age, BMI

SBP 5

2

5

22

Age and sex, multivariable

Cohort, sex, age, BMI

SBP 6

2

6

24

Age and sex, multivariable

Cohort, sex, age, BMI

PP 1

2

1

12

Age and sex, multivariable

Cohort, sex, age, BMI

PP 2

2

2

16

Age and sex, multivariable

Cohort, sex, age, BMI

PP 3

2

3

18

Age and sex, multivariable

Cohort, sex, age, BMI

PP 4

2

4

20

Age and sex, multivariable

Cohort, sex, age, BMI

PP 5

2

5

22

Age and sex, multivariable

Cohort, sex, age, BMI

PP 6

2

6

24

Age and sex, multivariable

Cohort, sex, age, BMI

PP 7

2

7

26

Age and sex, multivariable

Cohort, sex, age, BMI

PP 1–7

2

Mean of exams 1–7

Mean of exams 12, 16, 18, 20, 22, 24, 26

Age and sex, multivariable

Cohort, sex, age, BMI

Tonometry

1/CF-PWV

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

AI

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

CPP

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

CR-PWV

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

DBP-osc

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

PA-1

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

PA-2

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

PP-osc

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

RWTT

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

SBP-osc

2

7

Not included

Age and sex, multivariable

Sex, age, age^2, height, weight

  1. *n = number of phenotypes analyzed
  2. ^Association results for primary and secondary phenotypes are available on the worldwide web at: http://web.ncbi.nlm.nih.gov/projects/gap/framingham/cgi-bin/study.cgi?id=phs000007
  3. AI = augmentation index; CPP = central pulse pressure; CB-PWV = carotid brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; CR-PWV = carotid-radial pulse wave velocity; DBP = diastolic blood pressure; DBP-osc = brachial DBP by oscillometric device; FW = forward wave amplitude; MAP = mean arterial pressure; PA-1 = apparent peripheral amplification; PA-2 = true peripheral amplification; PP = pulse pressure; PP-osc = brachial PP by oscillometric device; RW = reflected wave amplitude; RWTT = reflected wave transit time; SBP = systolic blood pressure; SBP-osc = brachial SBP by oscillometric device; 1/CF-PWV = inverse of CF-PWV.
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BMC Medical Genetics

ISSN: 1471-2350

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