Table 2 Analysis of Serum measurements and PPAR alpha (L162V) in Caucasians
From: PPARα L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
Serum Measurement | Group | Covariates | P-value | N; Adjusted mean ± SEM | p-value for significantly different means | % variation explained by genotype; LRT p-value |
|---|---|---|---|---|---|---|
Triglycerides | All subjects | Age | 0.0026 | CC (N = 500; 102.92 ± 4.49)* CG (N = 71; 146.80 ± 11.84)* GG (N = 7; 114.99 ± 37.98) | *p = 0.0018 | 2.0%; 0.0025 |
Females | Age | 0.0474 | CC (N = 307; 94.76 ± 2.59)* CG (N = 45; 111.11 ± 6.77)* GG (N = 7; 114.72 ± 17.17) | NONE | 1.7%; 0.0458 | |
Males | Age | 0.0040 | CC (N = 193; 116.15 ± 10.82)* CG (N = 26; 207.49 ± 29.49)* | *p = 0.0040 | 3.8%; 0.0037 | |
HDL | All subjects | Age | 0.0076 | CC (N = 500; 48.13 ± 0.56) CG (N = 70; 44.67 ± 1.48)* GG (N = 7; 58.43 ± 4.74)* | *p = 0.0173 | 1.7%; 0.0073 |
Females | Age | NS | ||||
Males | Age | 0.0017 | CC (N = 193; 41.77 ± 0.78)* CG (N = 26; 34.54 ± 2.13)* | *p = 0.0017 | 4.4%; 0.0015 | |
Cholesterol | All subjects | Age | NS | |||
Females | Age | NS | ||||
Males | Age | NS | ||||
VLDL-TG | All subjects | Age | NS | |||
Females | Age | 0.0441 | CC (N = 307; 18.94 ± 0.52)* CG (N = 45; 22.29 ± 1.35)* GG (N = 7; 22.77 ± 3.43) | NONE | 1.7%; 0.0426 | |
Males | Age | NS | ||||
LDL | All subjects | Age | NS | |||
Females | Age | NS | ||||
Males | Age | NS | ||||
Fasting glucose | All subjects | Age | NS | |||
Females | Age | 0.0440 | CC (N = 307; 85.78 ± 0.41) CG (N = 45; 83.65 ± 1.03) GG (N = 7; 89.71 ± 2.58) | NONE | 1.5%;0.0426 | |
Males | Age | NS | ||||
Fasting insulin | All subjects | Age | NS | |||
Females | Age | NS | ||||
Males | Age | NS |