Figure 1From: Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD)Genetic analysis of GATA4. (A) Schematic representation of GATA4 (genomic, mRNA and protein level). Reference sequence for GATA4 was based on NM_002052 and the intron-exon boundaries on [42]. (B) Examples of 3'-UTR mutations and genotypes obtained after direct sequencing of fragments amplified from diseased cardiac tissues of patients affected by CHD. Additional sequence alterations in the 3'- UTR of GATA4 were detected, e.g. F24ASD (c.+281G>A).Back to article page