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Table 6 β3AR genotypes and bone mineral density: summary of previous and present studies

From: β3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)

First Author and genotypes

N (%)

Femoral neck BMD (mean; SD)

Lumbar spine BMD (mean; SD)

Total body BMD (mean; SD)

Ogawa et al. [38]a

    

Trp/Trp and Trp/Arg

267 (95.4)

NA

0.145 (1.36)

0.432 (0.93)

Arg/Arg

13 (4.6)

NA

0.179 (2.11)

-0.135 (0.93)

P-value

 

NA

NS

0.033

Kasumata et al. [27]b

    

Trp/Trp and Trp/Arg

142 (97.6)

NA

NA

NA

Arg/Arg

3 (2.4)

NA

NA

NA

P-value

 

NS

NS

NA

The present study

    

Trp/Trp

385 (86.3)

0.76 (0.13)

1.00 (0.18)

NA

Trp/Arg and Arg/Arg

61 (13.7)

0.79 (0.13)

1.04 (0.21)

NA

P-value

 

0.238

0.113

NA

  1. NA, not available; NS, non-significant. aValues were shown as Z-scores BMD. b Data were not shown; the authors only stated in text: "No association was demonstrated between the ER, CaSR or β3-AR genotypes and BMD, either alone or in relation to other polymorphisms".