Table 4 Characteristics of studies on NAT2 polymorphisms and Parkinson's disease: genetic and disease-association analyses
From: N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease
Authors, country | Samples | NAT2 variants | Assay | Statistical analysis | Slow acetylator PD cases (%) | Slow acetylator controls (%) | Association Yes/No |
|---|---|---|---|---|---|---|---|
Van der Walt et al. 2003, USA | blood | 282, 341,481,590, 857 | oligo ligation assay | pedigree disequilibrium test (PDT-sum), likelihood ratio test (Transmit), χ2-test | NG1 | NG1 | No overall, but marginal c.282 in EOPD |
Bandmann et al. 2000, UK | blood, brain tissue | 191, 341,282,481,590, 803, 857 | allele-specific CR, PCR-RFLP | χ2-test, OR 95% CI, Yate's correction | familial: 69.0 sporadic: 59.0 | 37.0 | Yes |
Bandmann et al. 1997, UK | blood, brain tissue | 481, 590, 857 | PCR-RFLP | χ2-test, OR 95% CI, Yate's correction | familial: 73 sporadic: 60 | 39.0 | Yes |
Nicholl et al. 1999, UK | blood | 481, 282, 590, 803, few cases: 191, 857 | PCR-RFLP | χ2-test, two-sample t- or Wilcoxon tests, OR 95% CI | familial: 53.3 sporadic: 60.1 | familial: 76.7 sporadic: 55.4 | No |
Chaudhary et al. 2005, India | blood | 191, 282, 341,481, 590, 803, 857 | PCR-RFLP | χ2-test, PHASE 2.0.2 for haplotypes, OR 95% CI | pooled: 19.2 EOPD: 25.78 LOPD: 12.29 | pooled: 13.45 EOPD control: 13.01 LOPD control: 13.78 | Yes, c.590 and c.857 in EOPD c.282 in LOPD |
Chan et al. 2003, China | blood | 481,590,857 | PCR-RFLP | logistic regression analysis, adjusted OR 95% CI | 68.7 | 28.6 | Yes |
Bialecka et al. 2002, Poland | blood | 481,590,803,857 | PCR-RFLP | χ2-test, OR 95% CI, Yate's correction | 64.8 | 46.9 | Yes |
Maraganore et al. 2000, USA | blood | 481,590, 857 | PCR-RFLP | logistic regression analysis, adjusted OR 95% CI, two-sided p values | 54.0 | 53.0 | No overall, but c.857 |
Dupret et al. 1999, France | blood | 191,341,590,857 | allele-specific PCR, PCR-RFLP | NG1 | 51.5 | 59.8 | No |
Harhangi et al. 1999, Netherlands | blood | 481,590, 857 | PCR-RFLP | OR 95% CI, Fischer's exact test two tailed | 54.0 | 53.0 | No |
Agundez et al. 1998, Spain | blood | 191, 282, 341, 590, 803, 857 | PCR-RFLP | χ2-test, OR 95% CI, Fischer's exact test | EOPD: 78.4 LOPD: 54.8 | 55.4 | No overall, but yes OEPD |