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Table 1 β and γ ENaC variants identified among the three study groups

From: Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

 

Hypertension n (%)

Normotensive males n (%)

Blood donors n (%)

Adjusted OR (95% CI)1

All variants

32 (9.2)

5 (2.9)**

9 (3.0)**

3.1 (1.6–6.0)

βENaC i12-17CT

16 (4.6)

2 (1.1)*

3 (1.0)**

4.6 (1.6–13.0)

βENaC G589S

8 (2.3)

2 (1.1)

3 (1.0)

2.4 (0.77–7.7)

γENaC V546I

8 (2.3)

1 (0.6)

3 (1.0)

2.2 (0.63–7.5)

Non-carriers

315 (90.8)

170 (97.1)

292 (97.0)

 
  1. *P<0.05 and **P<0.01 vs. Hypertension group.
  2. 1OR for hypertension (versus combined control groups) in ENaC variant carriers vs. non-carriers, adjusted for age and gender.
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BMC Medical Genetics

ISSN: 1471-2350

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