Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy: a systematic review and meta-analysis

Dellamea, Bruno Schmidt; Pinto, Lana Catani Ferreira; Leitão, Cristiane Bauermann; Santos, Katia Gonçalves; Canani, Luis Henrique Santos

doi:10.1186/1471-2350-15-9

Table 3 Meta-analysis in all genetic models with all patients and subgroup analysis, in fixed-model analysis, presenting heterogeneity (P _Q and I ² )

From: Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy: a systematic review and meta-analysis

	Population	Studies	OR	IC (95%)	P	P_Q	I²(%)
4b/a
Allele contrast	All	15	1.15	1.05-1,25	<0.01	<0.01	66
	African	2	0,98	0.81-1.18	0.88	0,25	22
	East Asians	6	1.21	0.97-1.50.8	0.08	0.29	18
	Whites	7	1.20	1.07-1.34	<0.01	<0.01	80
	Type 1	5	1.17	1.02-1.34	0.02	0.07	54
	Type 2	10	1.12	0.99-1.27	0.07	0.28	18
Additive	All	15	1.52	1.18-1.97	<0.01	<0.01	62
	African	2	1,13	0,69-1,81	0.62	0.56	0
	East Asians	6	3.25	1.58-6.68	<0.01	0.31	16
	Whites	7	1.49	1.06-2.08	0.01	<0.01	74
	Type 1	5	2.21	1.50-3.25	<0.01	<0.01	81
	Type 2	11	1.36	0.98-1.88	0.06	0.08	41
Recessive	All	15	1.50	1.16-1.93	<0.01	<0.01	64
	Africans	2	1.13	0.69-1.83	0,61	0.83	0
	East Asians	6	3.44	1.68-7.05	<0.01	0.28	21
	Whites	7	1.43	1.03-1.99	0.03	<0.01	75
	Type 1	5	2.19	1.49-3.21	<0.01	<0.01	81
	Type 2	11	1.49	1.07-2.07	0.02	0.08	42
Dominant	All	15	1.11	1.01-1.23	0.03	0,01	49
	African	2	0.94	0.75-1.18	0.64	0.24	27
	East Asians	6	1.04	0.81-1.34	0.71	0.44	0
	Whites	7	1.20	1.05-1.36	<0.01	<0.01	67
	Type 1	5	1.22	1.04-1.43	0.01	<0.01	78
	Type 2	11	1.05	0.92-1.20	0.44	0.62	0
Codominant	All	15	0.98	0.88-1.09	0.81	0,02	46
	African	2	1.09	0.87-1.38	0.42	0.29	7
	East Asians	6	1.17	0.90-1.55	0.22	0.14	38
	Whites	7	0.90	0.79-1.04	0.16	0.04	54
	Type 1	5	0.94	0.80-1.11	0.46	0.01	68
	Type 2	11	1.01	0.88-1.17	0.80	0.19	26
T-786C
Allele contrast	All	5	1.28	1.14-1.44	<0.01	0.25	24
	African	2	1.44	1.21-1.71	<0.01	0.26	19
	Whites	2	1.13	0.94-1.36	0.19	0.44	0
	Type 2	4	1.29	1.13-1.46	<0.01	0.15	42
Additive	All	5	1.48	1.14-1.92	<0,01	0.01	67
	African	2	1.43	0.98-2.09	0.05	0.01	84
	Whites	2	1.36	0.93-1.98	0.10	0.18	42
	Type 2	4	1.40	1.06-1.86	0.01	<0.01	73
Recessive	All	5	1.38	1,09-1.76	<0,01	0.01	68
	African	2	1.24	0.88-1.76	0.21	0.01	81
	Whites	2	1.39	0.98-1.95	0.06	0.09	0
	Type 2	4	1.27	0.98-1.65	0.06	0.01	72
Dominant	All	5	1.21	1,04-1.42	0.01	0.29	18
	African	2	1.39	1.11-1.73	<0.01	0.13	54
	Whites	2	1.05	0.81-1.37	0.70	0.95	0
	Type 2	4	1.24	1.05-1.47	<0.01	0.22	31
Codominant	All	5	0.95	0.81-1.11	0.53	0.12	45
	African	2	0.78	0.62-0.98	0.03	0.48	0
	Whites	2	1.15	0.89-1.49	0.28	0.24	25
	Type 2	3	0.90	0.75-1.06	0.20	0.131	15
G986T
Allele contrast	All	12	1.12	1.03-1.21	<0.01	<0.01	75
Allele contrast	African	3	1.63	1.39-1.91	<0.01	0.61	0
	East Asian	3	1.33	1.05-1.70	0.01	0.74	0
	Whites	4	0.93	0.84-1.04	0.20	0.67	0
	Type 1	2	0.92	0.80-1.04	0.18	0.18	0
	Type 2	9	1.27	1.15-1.42	<0.01	<0.01	72
Additive	All	12	1.19	0.99-1.43	0.05	<0.01	63
	African	3	2.01	1.50-2.94	<0.01	0.27	22
	East Asian	3	1.85	1,05-3.25	0.03	0.59	0
	Whites	4	0.86	0.67-1.10	0.23	0.69	0
	Type 1	2	0.87	0.65-1.16	0.34	0.44	0
	Type 2	9	1.47	1.16-1.86	<0.01	<0.01	63
Recessive	All	12	1.16	0.97-1.38	0.09	0.02	52
	Africa	3	1.80	1.31-2.46	<0.01	0.43	0
	East Asian	3	1.73	1.01-2.96	0.04	0.63	0
	Whites	4	0.88	0.69-1.11	0.29	0.62	0
	Type 1	2	0.91	0.69-1.20	0.49	0.31	0
	Type 2	9	1.36	1.08-1.70	<0.01	0.03	53
Dominant	All	12	0.99	0.89-1.11	0.92	0.07	45
	African	3	1.46	1.17-1.82	<0.01	0.11	54
	East Asian	3	1.32	0.98-1.79	0.06	0.73	0
	Whites	4	0.93	0.80-1.07	0.31	0.59	0
	Type 1	2	0.89	0.75-1.06	0.19	0.74	0
	Type 2	9	1.19	0.92-1.26	0.35	0.04	57
Codominant	All	12	1.03	1.04-1.37	0.01	0.01	60
	African	3	0.92	0.74-1.14	0.45	0.29	18
	East Asian	3	0.89	0.65-1.21	0.48	0.52	0
	Whites	4	1.02	0.89-1.18	0.69	0.44	0
	Type 1	2	1.08	0.91-1.29	0.35	0.32	0
	Type 2	9	0.94	0.82-1.08	0.41	0.34	11

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com

BMC Medical Genetics

Contact us