Figure 3
From: The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML)
The miR-663 promoter is methylated in pediatric AML. (A) MSP analysis of the methylation status of miR-663 shows aberrant methylation in pediatric AML samples compared to NBM/ITP control samples. M and U represent MSP results using primer sets for methylated and unmethylated miR-663 genes, respectively. (B) BGS results of three AML samples and three NBM samples show that CpGs are methylated in the AML samples compared to NBM control samples (91.3%, 84.8%, and 72.5% in AML10#, AML11#, and AML18#, respectively; 7.24%, 9.42%, and 9.42% in NBM1#, NBM2#, and NBM3#, respectively). ● methylated cytosines; ○ unmethylated cytosines.