Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

BMC Medical Genetics

Table 3 Comparison of genotype and allele frequencies for TNF-α, IFN-γ, and IL-6 in IPF patients and healthy controls

Cytokine/Genotype/Allele	IPF	Healthy controls	*p-value	OR	95% CI
	(n = 60)	(n = 150)
TNF-α (−308)
AA^a	4 (6.7)	9 (6)	0.856	0.894	0.264 – 3.020
AG^b	19 (31.7)	38 (25.3)	0.392	0.732	0.380 – 1.412
GG^c	37 (61.7)	103 (68.7)	0.336	1.362	0.730 – 2.544
A allele^d	27 (22.5)	56 (18.7)	0.416	0.791	0.471 – 1.327
G allele	93 (77.5)	244 (81.3)
IFN-γ (+874)
TT^e	15 (25)	35 (23.3)	0.858	0.913	0.455 – 1.832
AT^f	23 (38.3)	73 (48.7)	0.220	1.525	0.828 – 2.810
AA^g	22 (36.7)	42 (28)	0.247	0.672	0.356 – 1.267
T allele^h	53 (44.2)	143 (47.7)	0.588	0.868	0.567 – 1.329
A allele	67 (55.8)	157 (52.3)
IL-6 (−174)
CCⁱ	4 (6.7)	9 (6)	0.856	0.894	0.264 – 3.020
CG^j	11 (18.3)	33 (22)	0.708	1.256	0.588 – 2.685
GG^k	45 (75)	108 (72)	0.733	0.857	0.432 – 1.699
C allele^l	19 (15.8)	51 (17)	0.885	1.089	0.612 – 1.935
G allele	101 (84.2)	249 (83)

Data are presented as number (with percentages).
Abbreviations: TNF-α tumor necrosis factor alpha, IFN-γ interferon gamma, IL interleukin, IPF idiopathic pulmonary fibrosis, OR odds ratio, CI confidence interval.
*Chi-square or Fisher’s exact tests were used to compare frequencies between genotypes and alleles.
^aAA vs. GG and AG genotypes.
^bAG vs. AA and GG genotypes.
^cGG vs. AG and AA genotypes.
^dA vs. G allele.
^eTT vs. AT and AA genotypes.
^fAT vs. AA and TT genotypes.
^gAA vs. TT and AT genotypes.
^hT vs. A allele.
ⁱCC vs. GG and CG genotypes.
^jCG vs. CC and GG genotypes.
^kGG vs. CG and CC genotypes.
^lC vs. G allele.

ISSN: 1471-2350