From: Genetic interaction of GSH metabolic pathway genes in cystic fibrosis
Clinical variables | Gene | Ratio | Testing ball. acc. | p-value | Cross validation consistency | |
---|---|---|---|---|---|---|
Male/female | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 1 | 0.5056 | 0.8506 | 10/10 | |
Race (caucasian/ no caucasian) | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.0909 | 0.3909 | 0.9915 | 10/10 | |
Age | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9889 | 0.5312 | 0.6870 | 10/10 | |
Age for diagnosis | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.8804 | 0.4100 | 0.9989 | 10/10 | |
Onset of symptoms | geral | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.7526 | 0.4286 | 0.9945 | 10/10 |
digestive | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9737 | 0.4614 | 0.9698 | 10/10 | |
pulmonary | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.7935 | 0.5022 | 0.8566 | 10/10 | |
Clinical scores | Bhalla | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9552 | 0.6824 | 0.0080 # | 10/10 |
Kanga | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9571 | 0.5131 | 0.8165 | 10/10 | |
Shwachman-Kulczycki | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9 | 0.5562 | 0.5474 | 10/10 | |
Body mass index | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 3.45 | 0.5484 | 0.6260 | 10/10 | |
Sputum’s microbiology | A. xylosoxidans | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.1118 | 0.4617 | 0.9418 | 10/10 |
P. aeruginosa mucoid | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.7379 | 0.5505 | 0.5507 | 10/10 | |
P. aeruginosa no mucoid | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 1.2949 | 0.4151 | 0.9951 | 10/10 | |
S. aureus | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 3.7105 | 0.5094 | 0.8317 | 6/10 | |
B. cepacia | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.1548 | 0.5277 | 0.7610 | 10/10 | |
First isolated P. aeruginosa | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9552 | 0.4913 | 0.8903 | 7/10 | |
Hemoglobin oxygen saturation in the blood | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9602 | 0.5312 | 0.6904 | 10/10 | |
Spirometry | FEV1 | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9848 | 0.4746 | 0.9448 | 10/10 |
FVC(%) | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.900 | 0.4437 | 0.9833 | 10/10 | |
FEV1/FVC(%) | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9403 | 0.6426 | 0.0586 | 10/10 | |
FEF25-75% | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.9848 | 0.5054 | 0.8447 | 10/10 | |
Comorbidities | Pancreatic insufficiency | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 3.977 | 0.5266 | 0.7486 | 10/10 |
Meconium ileus | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.1776 | 0.5401 | 0.6950 | 10/10 | |
Nasal polyps | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.2292 | 0.5713 | 0.5139 | 10/10 | |
Diabetes mellitus | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.2292 | 0.4527 | 0.9728 | 10/10 | |
Osteoporosis | CFTR*GCLC*GSTP1*GSTT1*GSTM1 | 0.1959 | 0.3815 | 0.9988 | 10/10 |