Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity

Table 3 Association of MMP1 locus haplotypes with MMP1 level

	SNP 1	SNP 2	SNP 3	SNP 4	SNP 5	Frequency	Coefficient	SE	t.stat	P value	Adjusted P value
H1	A	2G	T	A	A	38.56%	−0.2311	0.0660	−3.5029	5.02x10^-4	0.005
H2	A	1G	T	A	G	17.47%	0.3304	0.0834	3.9635	8.47x10^-5	8.47 x10^-4
H3	A	2G	T	A	G	9.66%	0.1597	0.1103	1.4481	0.148	1
H4	A	2G	T	G	A	6.61%	−0.0533	0.1570	−0.3392	0.735	1
H5	G	2G	T	A	A	5.62%	−0.2479	0.1394	−1.7782	0.076	0.760
H6	A	1G	C	A	G	5.48%	0.1326	0.1440	0.9212	0.357	1
H7	A	1G	T	A	A	4.47%	0.1285	0.1697	0.7572	0.449	1
H8	G	1G	T	A	G	2.87%	−0.4000	0.2532	−1.5798	0.115	1
H9	A	1G	T	G	G	2.65%	0.2969	0.2400	1.2373	0.217	1
H10	G	2G	T	A	G	1.81%	−0.1032	0.2987	−0.3457	0.730	1

SNP1: rs11226373, SNP2: rs1799750, SNP3: rs1144393, SNP4: rs514921, SNP5: rs495366.
Coefficients and P values were estimated based on haplotype trend regression analysis implemented in the HelixTree program. The selected haplotype compared to all other unselected haplotypes; adjusted for age, sex, smoking, and BMI.
Adjusted P values were computed by the Bonferroni method.

ISSN: 1471-2350