Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)

Goodloe, Robert; Brown-Gentry, Kristin; Gillani, Niloufar B; Jin, Hailing; Mayo, Ping; Allen, Melissa; McClellan, Bob; Boston, Jonathan; Sutcliffe, Cara; Schnetz-Boutaud, Nathalie; Dilks, Holli H; Crawford, Dana C

doi:10.1186/1471-2350-14-120

Table 2 Significant tests of association for gallstone disease by population

From: Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)

SNPs	Gene	OAT	Non-Hispanic Whites			Non-Hispanic Blacks			Mexican Americans
SNPs	Gene	OAT	Case/ Control CAF	OR (95% C.I.)	P	Case/ Control CAF	OR (95% C.I.)	P	Case/ Control CAF	OR (95% C.I.)	P
rs10401969	SUGP1	TG	§	1.37 (1.05, 1.78)	*1.89E-02*	§	1.01 (0.74, 1.38)	9.61E-01	§	0.69 (0.41, 1.15)	1.52E-01
rs10889353	DOCK7	TG	0.64/ 0.67	0.90 (0.76, 1.05)	1.83E-01	0.61/ 0.62	0.84 (0.67, 1.06)	1.50E-01	0.66/ 0.62	1.32 (1.05, 1.67)	*1.73E-02*
rs17216525	CILP2	TG	§	0.76 (0.58, 0.99)	*4.45E-02*	§	1.26 (0.64, 2.46)	5.02E-01	§	0.88 (0.53, 1.45)	6.15E-01
rs1883025	ABCA1	HDL	0.27/ 0.26	1.09 (0.92, 1.30)	3.36E-01	0.30/ 0.33	0.84 (0.66, 1.09)	1.86E-01	0.26/ 0.28	0.78 (0.62, 0.98)	*3.30E-02*
rs2650000	HNF1A LEF1	LDL	0.66/ 0.65	1.146 (0.97, 1.35)	1.02E-01	§	1.50 (1.02, 2.21)	*3.73E-02*	0.63/ 0.63	0.976 (0.79, 1.20)	8.21E-01
rs28927680	BUD13	HDL TG	0.09/ 0.07	1.23 (0.93, 1.62)	1.53E-01	0.22/ 0.17	1.40 (1.06, 1.86)	*1.92E-02*	0.16/ 0.14	1.07 (0.81, 1.42)	6.27E-01
rs3764261	CETP	HDL	0.68/ 0.68	0.95 (0.80, 1.12)	5.15E-01	0.63/ 0.69	0.71 (0.56, 0.90)	*4.70E-03*	0.66/ 0.66	1.06 (0.85, 1.33)	5.89E-01
rs4149268	ABCA1	HDL	0.38/ 0.38	1.10 (0.94, 1.30)	2.34E-01	0.69/ 0.65	1.03 (0.81, 1.31)	8.21E-01	0.30/ 0.33	0.75 (0.60, 0.95)	*1.53E-02*
rs4939883	LIPG	HDL	0.83/ 0.83	1.28 (1.03, 1.59)	*2.71E-02*	0.56/ 0.54	0.94 (0.75, 1.19)	6.17E-01	§	0.88 (0.65, 1.19)	4.14E-01
rs6544713	ABCG8	LDL	0.71/ 0.68	1.35 (1.14, 1.61)	*7.00E-04*	§	1.19 (0.88, 1.62)	2.65E-01	0.85/ 0.82	1.22 (0.92, 1.60)	1.66E-01
rs6756629	ABCG5	LDL	0.09/ 0.06	1.89 (1.44, 2.49)	*1.00E-04*	0.13/ 0.08	1.24 (0.82, 1.87)	3.03E-01	0.12/ 0.09	1.19 (0.85, 1.67)	3.04E-01
rs754523	APOB	LDL	0.33/ 0.32	1.02 (0.86, 1.20)	8.34E-01	0.27/ 0.22	1.36 (1.04, 1.78)	*2.41E-02*	0.24/ 0.29	0.86 (0.68, 1.08)	1.82E-01
rs7679	PCIF1	HDL	0.19/ 0.16	0.97 (0.79, 1.19)	7.45E-01	§	1.18 (0.75, 1.84)	4.73E-01	0.14/ 0.11	1.51 (1.13, 2.01)	*4.80E-03*

Single SNP tests of association were performed using logistic regression assuming an additive genetic model. Only results for SNPs associated at p < 0.05 in any one race/ethnicity are shown (bolded and italicized). Results displayed here were adjusted for age, sex, and body mass index. §Per data use agreement, coded allele frequencies are not outputted by CDC for cells with ≤5 counts.
Abbreviations: Original associated Trait (OAT); High density lipoprotein cholesterol (HDL-C); low density lipoprotein cholesterol (LDL-C); triglycerides (TG); coded allele frequency (CAF); odds ratio (OR); confidence interval (CI); p-value (P).

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