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Table 1 Baseline characteristics stratified by HCV genotype

From: PNPLA 3I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection

 

HCV genotype 2 n = 103

HCV genotype 3 n = 256

P value

Male gender, n (%)

62 (60)

154 (60)

0.920

Age, years

49 (41–54)

40 (32–48)

<0.001

BMI, kg/m 2

25a (23–27)

25b (23–28)

0.290

ALT, U/l

74a (44–144)

108a (66–175)

<0.001

Total cholesterol, mmol/L

4.6c (4.1-5.4)

3.9d (3.3-4.6)

<0.001

Triglycerides, mmol/L

0.9c (0.7-1.3)

0.9d (0.7-1.4)

0.748

Glucose, mmol/L

4.9d (4.6-5.4)

4.9e (4.5-5.4)

0.507

Insulin, mIU/L

12f (6–24)

12e (7–26)

0.458

HOMA-IR, U

2.5g (1.3-6.0)

2.7h (1.6-5.9)

0.088

Baseline HCV RNA, log 10 IU/mL

6.5 (5.8-6.8)

6.1 (5.4-6.7)

0.025

Steatosis 1 , n (%)

49c (50)

171i (73)

<0.001

Cirrhosis 2 , n (%)

14c (14)

29i (12)

0.807

Diabetes mellitus, n (%)

4d (4)

7e (3)

0.823

  1. Categorical traits, expressed as number (n) and relative proportion (%), have been compared by χ 2 test. Continuous traits are expressed as median (interquartile range) and have been analyzed using a linear regression model. For additional information on statistical analyses, see methods.
  2. 1Steatosis was defined as histological grade > 0. 2Cirrhosis was defined as Ishak stage 5–6.
  3. Missing data: an = 1, bn = 8, cn = 4, dn = 6, en = 15, fn = 7, gn = 13, hn = 27,in = 23.
  4. Abbreviations: HCV, hepatitis C virus; BMI, body mass index; ALT, alanine transferase; HOMA-IR, homeostasis model assessment for insulin resistance; II, individuals with two 148I alleles; MM, individuals with two 148 M alleles; IM, heterozygotes.
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BMC Medical Genetics

ISSN: 1471-2350

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