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Figure 1 | BMC Medical Genetics

Figure 1

From: Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

Figure 1

Computational prediction of miRNAs binding to ADAM10 3'UTR. Three programs RNA22, RNAhybrid and miRanda are used for the prediction of miRNAs binding to the human ADAM10 3'UTR. After retrieving a list of 236 miRNAs by RNA22, RNAhybrid or miRanda we extracted the relevant miRNAs according to selection criteria: prediction by at least two programs, differential regulation in AD patients (Cogswell et al. 2008), tissue-specific expression (MGI), binding to AD key genes, corresponding mouse miRNA binding to the mouse ADAM10 3'UTR sequence predicted by at least two of the three programs, additional prediction by TargetScan and microRNA, occurrence of multiple binding sites and evolutionary conservation.

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BMC Medical Genetics

ISSN: 1471-2350

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