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Table 3 Association of significant EMID2 variants with nasal polyps in AERD patients (n = 114)

From: Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients

SNP/Haplotype

MAF

 

Co-dominant

  

Dominant

  

Recessive

  
 

Polyp-positive (n = 66)

Polyp-negative (n = 48)

OR(95%CI)

P*

P corr **

OR(95%CI)

P*

P corr **

OR(95%CI)

P*

P corr **

rs6945102C > T

0.205

0.365

0.43(0.22-0.84)

0.01

NS

0.39(0.17-0.86)

0.02

NS

0.27(0.05-1.51)

0.14

-

rs4729697A > G

0.200

0.365

0.42(0.22-0.83)

0.01

NS

0.38(0.17-0.84)

0.02

NS

0.27(0.05-1.57)

0.15

-

rs10237610C > T

0.554

0.438

1.82(1.01-3.29)

0.05

NS

1.50(0.60-3.73)

0.38

-

3.42(1.22-9.60)

0.02

NS

rs221G > A

0.208

0.396

0.35(0.18-0.70)

0.003

NS

0.35(0.16-0.78)

0.01

NS

0.10(0.01-0.87)

0.04

NS

rs10435333G > A

0.212

0.396

0.36(0.18-0.71)

0.003

NS

0.36(0.16-0.81)

0.01

NS

0.09(0.01-0.85)

0.04

NS

rs9640666G > A

0.326

0.479

0.46(0.25-0.86)

0.02

NS

0.35(0.15-0.84)

0.02

NS

0.43(0.14-1.35)

0.15

-

rs6947185C > A

0.400

0.531

0.52(0.28-0.94)

0.03

NS

0.27(0.10-0.74)

0.01

NS

0.65(0.25-1.69)

0.37

-

rs4729705C > T

0.371

0.521

0.50(0.28-0.88)

0.02

NS

0.25(0.10-0.63)

0.003

NS

0.66(0.25-1.70)

0.38

-

rs10254310G > A

0.432

0.552

0.58(0.34-1.01)

0.06

-

0.39(0.15-0.98)

0.04

NS

0.60(0.25-1.46)

0.26

-

rs6949799T > C

0.546

0.417

1.77(1.02-3.08)

0.04

NS

1.83(0.77-4.34)

0.17

-

2.61(1.00-6.80)

0.05

NS

rs4727491G > A

0.538

0.417

1.74(1.00-3.05)

0.05

NS

1.83(0.77-4.34)

0.17

-

2.48(0.95-6.51)

0.06

-

rs13238748G > C

0.371

0.521

0.50(0.28-0.88)

0.02

NS

0.25(0.10-0.63)

0.003

NS

0.66(0.25-1.70)

0.38

-

rs4727494G > A

0.220

0.385

0.46(0.25-0.86)

0.01

NS

0.37(0.16-0.84)

0.02

NS

0.36(0.10-1.37)

0.14

-

rs13233066G > A

0.227

0.385

0.49(0.27-0.90)

0.02

NS

0.37(0.16-0.84)

0.02

NS

0.45(0.13-1.58)

0.21

-

EMID2_BL1_ht1

0.538

0.417

1.83(1.02-3.26)

0.04

NS

1.38(0.58-3.31)

0.47

-

4.23(1.42-12.57)

0.01

NS

EMID2_BL1_ht2

0.159

0.323

0.37(0.18-0.77)

0.008

NS

0.34(0.15-0.77)

0.01

NS

0.22(0.02-2.18)

0.19

-

EMID2_BL2_ht2

0.220

0.385

0.46(0.25-0.86)

0.01

NS

0.37(0.16-0.84)

0.02

NS

0.36(0.10-1.37)

0.14

-

  1. *P-values at 0.05 level of significance adjusted for initial diagnosed age, sex, smoking status, and atopy. Significant values are shown in bold.
  2. **P-values after multiple testing corrections (Meff = 42.7377).
  3. MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; NS, not significant.
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BMC Medical Genetics

ISSN: 1471-2350

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