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Table 3 Haplotype analysis of 13 PON2 tagSNPs in relation to PON activity adjusted for disease status, age, BMI, smoking, PON1/rs662 (p.Gln192Arg), PON1/rs854560 (p.Leu55Met), and PON3/rs17884563

From: Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus

 

Haplotypes

 

Hap 1

Hap 2

Hap 3

Hap 4

Hap 5

Hap 6

Hap Rare

Hap Base

PON2/ rs17876205

G

G

G

G

G

G

*

G

PON2/ rs13306702

G

G

G

G

G

G

*

G

PON2/ rs6954345 (p.Ser311Cys)

C

C

C

C

C

G

*

C

PON2/ rs9641164

A

A

A

T

T

A

*

A

PON2/ rs987539

C

C

C

T

T

T

*

C

PON2/ rs17876116

G

G

G

G

G

G

*

G

PON2/ rs2286233

A

T

T

A

A

A

*

A

PON2/ rs11981433

C

T

T

T

T

T

*

C

PON2/ rs11982486

T

T

T

T

T

T

*

C

PON2/ rs4729189

T

T

T

A

A

A

*

A

PON2/ rs10261470

A

A

G

G

G

G

*

G

PON2/ rs2299267

A

A

A

A

G

A

*

A

PON2/ rs17876183

G

G

G

G

G

G

*

G

Haplotype Frequency

0.073

0.051

0.052

0.052

0.096

0.192

0.161

0.323

Coefficient

0.21

1.14

0.31

0.47

-0.57

1.66

0.06

 

Standard Error

0.56

0.72

0.68

0.70

0.80

0.41

0.44

 

T statistic

0.38

1.59

0.46

0.67

-0.72

4.04

0.14

 

P

0.705

0.113

0.643

0.506

0.475

6.1 × 10-5

0.890

 
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BMC Medical Genetics

ISSN: 1471-2350

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