From: UGT1A1 sequence variants and bilirubin levels in early postnatal life: a quantitative approach
3a | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
---|---|---|---|---|---|---|---|---|---|---|
Individual | Chr. pos. | Exon | Gene pos. | AA pos. | SNP change | (TA) rpt | Typea | original AA | new AA | Â |
MS003 | 234334120 | 1A | 449 | 150 | C → T | 6/7 | N/S | Threonine | Methionine |  |
MS036 | 234333883 | 1A | 211 | 71 | G → A | 6/6 | N/S | Glycine | Arginine |  |
MS057 | 234333883 | 1A | 211 | 71 | G → A | 6/7 | N/S | Glycine | Arginine |  |
MS039 | 234334012 | 1A | 341 | 114 | A → G | 7/7 | N/S | Lysine | Arginine |  |
MS081 | 234334211 | 1A | 540 | 180 | A → G | 6/6 | S | Glutamic Acid | Glutamic Acid |  |
3b | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Individual | Maternal ethnicity | GA | % wt loss b | Feeding method | Initial bilirubin | Initial risk zone c | Repeat bilirubin | Repeat risk zone c | Bilirubin increase (mg/dl per hr) | Required Phototherapy |
MS003 | Caucasian | 37.0 | 6.4% | Breast | 10.2 | LI | 16.9 | High | 0.29 | Yes |
MS036 | Asian | 37.0 | 7.7% | Breast | 13.6 | High | 20.9 | High | 0.16 | Yes |
MS057 | Asian | 37.4 | -0.4% | Bottle | 12.5 | LI | 15.0 | HI | 0.16 | No |
MS039 | Caucasian | 39.4 | 3.1% | Bottle | 11.3 | HI | 10.3 | Low | -0.02 | No |
MS081 | Caucasian | 39.9 | 4.9% | Breast | 12.2 | HI | 14.9 | HI | 0.10 | No |