Table 4 Estimated haplotype probabilities and χ2- test showing haplotype association between KCNQ1 SNPs (rs231362, rs2237892, rs2237895) and T2D

ACC

0.12

0.11

1.94

0.86 (0.70 -1.05)

0.145

0.184

0.489

GCC

0.30

0.34

7.65

1.22 (1.07 -1.39)

0.002

0.004

0.006

ACA

0.14

0.12

7.39

0.74 (0.61-0.90)

0.003

0.007

0.019

GCA

0.44

0.44

0.02

1.02 (0.91-1.15)

0.743

0.836

0.997

global χ² = 12.9, df = 3, p = 0.005

US Cohort

Haplotype

NG

T2D

χ²

Adjusted OR (95%CI)

Unadjusted p

Adjusted p

Permutation p (5000)

ACC

0.10

0.13

1.61

1.67 (1.03 - 2.72)

0.142

0.135

0.507

GCC

0.30

0.35

2.58

1.22 (0.90 - 1.65 )

0.137

0.101

0.496

ACA

0.14

0.11

1.53

0.72 (0.44 - 1.17)

0.350

0.233

0.878

GCA

0.46

0.41

2.06

0.88 (0.66 - 1.19)

0.176

0.197

0.575

global χ² = 7.05, df = 3, p = 0.070

Combined (Punjabi + US Cohorts)

Haplotype

NG

T2D

χ²

Adjusted OR (95%CI)

Unadjusted p

Adjusted p

Permutation p (5000)

ACC

0.12

0.11

0.31

0.96 (0.80 -1.15)

0.644

0.611

0.985

GCC

0.30

0.34

10.1

1.22 (1.09 -1.36)

4.07 × 10 ^-4

0.001

8.00 × 10 ^-4

ACA

0.14

0.12

8.37

0.77 (0.64 -0.91)

0.002

0.002

0.011

GCA

0.44

0.44

0.45

0.98 (0.88 -1.09)

0.734

0.826

0.991

global χ² = 14.1, df = 3, p = 0.003