Table 6 Genotype and allele frequencies of RPSA 5-UTR -8T>C polymorphism according to the PRNP codon 129 or 219 status

Genotype frequency, n (%)

TT

84 (46.7)

7 (7.8)

-

87 (48.3)

-

-

TC

75 (41.7)

2 (2.2)

-

78 (43.3)

-

-

0.233

0.570

CC

21 (11.6)

0 (0)

-

15 (8.3)

-

-

Allele frequency

T

0.68

0.89

-

0.70

-

-

0.057

0.469

C

0.32

0.11

-

0.30

-

-

PRNP 219

Healthy controls (n = 189)

Sporadic CJD patients (n = 180)

P- value ³

P- value ⁴

EE (n = 173)

EK (n = 16)

KK (n = 0)

EE (n = 180)

EK (n = 0)

KK (n = 0)

Genotype frequency, n (%)

TT

86 (49.7)

5 (31.3)

-

87 (48.3)

-

-

TC

68 (39.3)

9 (56.3)

-

78 (43.3)

-

-

0.338

0.600

CC

19 (11.0)

2 (12.4)

-

15 (8.3)

-

-

Allele frequency

T

0.69

0.59

-

0.70

-

-

0.244

0.854

C

0.31

0.41

-

0.30

-

-