Skip to main content

Table 3 Crude and adjusted haplotype analysis for blood lipid levels by race/ethnicity - NHANES III (1991-1994)

From: Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

Genetic Variant

Haplotype

Non-Hispanic White

Non-Hispanic Black

Mexican American

  

β (95% CI)

FDR-adjusted P value*

β (95% CI)

FDR-adjusted P value

β (95% CI)

FDR-adjusted P value

Crude Analysis

High-density lipoprotein cholesterol

PON1

A-A

-6.56

(-13.78,0.66)

0.3814

-0.91

(-8.16,6.35)

0.9641

6.81

(2.89,10.73)

0.0179

 

A-G

-7.94

(-25.71,9.83)

0.697

-1.45

(-9.49,6.59)

0.9641

22.04

(4.73,39.34)

0.0777

 

T-A

-3.75

(-7.46,-0.05)

0.3814

-0.12

(-5.58,5.34)

0.9641

1.03

(-3.09,5.14)

0.8002

 

T-G

REF

 

REF

 

REF

 

Low-density lipoprotein cholesterol

APOE

C-C

12.12

(-4.40,28.64)

0.2499

4.92

(-5.58,15.41)

0.9016

15.43

(5.73,25.14)

0.0494

 

T-C

REF

 

REF

 

REF

 
 

T-T

-30.86

(-56.47,-5.25)

0.1066

-40.25

(-57.28,-23.22)

0.001

-38.64

(-67.23,-10.05)

0.0721

NOS3

C-G

-6.17

(-19.32,6.98)

0.4971

2.26

(-15.53,20.05)

0.9861

-0.62

(-10.80,9.56)

0.9665

 

C-T

3.85

(-11.06,18.76)

0.7161

38.05

(4.28,71.81)

0.1927

0.24

(-11.33,11.80)

0.9665

 

T-G

REF

 

REF

 

REF

 
 

T-T

0.82

(-23.44,25.08)

0.9704

2.94

(-11.50,17.37)

0.9861

-20.78

(-34.52,-7.03)

0.0494

PON1

A-A

10.91

(-0.74,22.56)

0.1706

4.89

(-12.82,22.60)

0.9861

2.45

(-9.04,13.94)

0.8789

 

A-G

46.49

(21.16,71.82)

0.0063

8.91

(-12.85,30.68)

0.9016

6.44

(-25.95,38.84)

0.8789

 

T-A

8.98

(-2.58,20.53)

0.247

-1.09

(-11.58,9.40)

0.9861

-2.04

(-8.21,4.13)

0.8789

 

T-G

REF

 

REF

 

REF

 

Total serum cholesterol

APOE

C-C

14.28

(-2.27,30.82)

0.2221

6.28

(-4.99,17.54)

0.7536

15.21

(2.29,28.14)

0.3143

 

T-C

REF

 

REF

 

REF

 
 

T-T

-24.87

(-51.22,1.48)

0.2172

-31.33

(-50.53,-12.13)

0.052

-19.40

(-38.15,-0.64)

0.3143

Adjusted Analysis**

High-density lipoprotein cholesterol

PON1

A-A

-4.86

(-11.20,1.48)

0.4856

-1.92

(-9.08,5.24)

0.8857

6.14

(3.44,8.84)

0.0021

 

A-G

-5.79

(-14.56,2.98)

0.4856

2.17

(-5.89,10.24)

0.8857

19.62

(6.84,32.39)

0.0441

 

T-A

-3.22

(-6.60,0.17)

0.4856

1.52 (-4.67,7.71)

0.8857

1.23 (-2.73,5.20)

0.7102

 

T-G

REF

 

REF

 

REF

 

Low-density lipoprotein cholesterol

APOE

C-C

12.93 (-3.41,29.26)

0.3459

4.01 (-8.26,16.28)

0.8555

21.28 (13.93,28.64)

<.0001

 

T-C

REF

 

REF

 

REF

 
 

T-T

-31.14 (-56.65,-5.64)

0.0992

-44.33 (-59.39,-29.27)

<.0001

-43.23 (-64.13,-22.34)

0.0016

NOS3

C-G

-3.42 (-15.49,8.65)

0.676

2.68 (-13.71,19.06)

0.8555

-3.05 (-8.55,2.46)

0.6162

 

C-T

6.48 (-10.27,23.22)

0.6032

31.18 (4.64,57.72)

0.233

-0.69 (-10.02,8.64)

0.9344

 

T-G

REF

 

REF

 

REF

 
 

T-T

1.64 (-20.75,24.03)

0.8806

1.95 (-10.32,14.21)

0.8555

-32.14 (-47.72,-16.55)

0.0016

PON1

A-A

8.77 (-5.24,22.77)

0.4865

8.10 (-9.66,25.85)

0.8555

-2.54 (-15.41,10.32)

0.8479

 

A-G

40.03 (19.65,60.41)

0.0053

10.90 (-12.43,34.24)

0.8555

9.62 (-21.64,40.88)

0.7428

 

T-A

9.78 (-0.77,20.33)

0.2366

-2.95 (-13.93,8.03)

0.8555

-3.33 (-12.53,5.87)

0.7428

 

T-G

REF

 

REF

 

REF

 

Total serum cholesterol

APOE

C-C

16.52 (0.51,32.53)

0.153

5.32 (-8.35,18.99)

0.8062

22.41 (14.73,30.10)

<.0001

 

T-C

REF

 

REF

 

REF

 
 

T-T

-27.18 (-52.46,-1.90)

0.153

-40.42 (-57.41,-23.43)

0.002

-25.23 (-39.80,-10.66)

0.0119

  1. β, beta coefficient; CI, confidence interval; REF reference group.
  2. *P-value was based on Satterthwaite-adjusted F test and adjusted for multiple comparisons using false discovery rate within each race/ethnicity group.
  3. **Adjusted for age, sex, education, body mass index, smoking status, alcohol intake, physical activity, dietary fat intake.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us